PMID: 30016535Jul 18, 2018Paper

Anti-NMDAR encephalitis as a serious adverse event probably related to yellow fever vaccination

Klinická mikrobiologie a infekc̆ní lékar̆ství
Lubomíra HozákováŠárka Blahutová

Abstract

We present a case of a 17-year-old female with anti-NMDAR encephalitis probably associated with vaccination against yellow fever. Her symptoms occurred 27 days after vaccination against yellow fever. Anti-NMDAR encephalitis manifested as acute psychosis, memory loss and catatonia following fever with complex partial epileptic seizures. Interictal electroencephalogram showed slow-wave delta background activity with "delta brushes". The diagnosis was confirmed by NMDAR antibody positivity in serum and cerebrospinal fluid. Since ovarian teratoma, as the most common cause of anti-NMDAR encephalitis, did not develop within five years from its onset, the association with vaccination against yellow fever seems to be highly probable.

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