Anti-nociceptive and anti-inflammatory effects of cyanocobalamin (vitamin B12) against acute and chronic pain and inflammation in mice

Arzneimittel-Forschung
H HosseinzadehL Etemad

Abstract

In this study, the anti-nociceptive and anti-inflammatory effects of cyanocobalamin (Vit B12) against acute and chronic pain and inflammation were evaluated in mice. Vit B12 (0.87, 1 and 1.77 mg/kg) were injected intraperitoneally. The anti-nociceptive effects against acute pain were examined using hot-plate and writhing tests. The chronic pain was examined 14 days after sciatic nerve ligation using the hot-plate test. Morphine (10 mg/kg) was used as a positive control. Anti-inflammatory effects of Vit B12 against acute and chronic inflammation were assessed using xylene-induced edema in ears and granuloma caused by compressed cotton implantation, respectively. In these tests, sodium diclofenac (15 mg/kg) was used as a positive control. Vit B12 showed a dose related effect in acute anti-nociceptive test and increased the anti-nociceptive effect of morphine in chronic treatment. Vit B12 demonstrated an anti-nociceptive effect in chronic studies as single or continues daily treatment and increased significantly the anti-nociceptive effect of morphine. All doses of Vit B12 significantly decreased xylene-induced ear edema. Maximum anti-inflammatory effect (37.5%) was obtained at dose of 1 mg/kg. In chronic inflammation, Vit B12 sig...Continue Reading

Citations

Sep 30, 2014·Peptides·Richard J Bodnar
Jan 28, 2016·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Gang XǔJie Xu
Sep 19, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Carlos-Alberto Calderon-OspinaCarlos Emilio Arbeláez Ariza
Nov 16, 2016·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·P R Kamchatnov
Oct 21, 2017·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·O A Shavlovskaya

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