Anti-Nociceptive Effect and Standardization from Mixture of Agrimonia pilosa Ledeb and Salvia miltiorrhiza Bunge Extracts

Journal of Medicinal Food
Seung Hwan HwangSoon Sung Lim

Abstract

Agrimonia pilosa Ledeb has been previously reported to produce an anti-nociceptive effect in ICR mice in both tail-flick and hot-plate tests. Studies have shown that Salvia miltiorrhiza Bunge, also renowned in traditional Chinese medicine, is an effective anti-inflammatory treatment. Among the extraction solvents investigated, a 50% ethanol (EtOH) extract of A. pilosa produced the highest anti-nociceptive effect in monosodium uric acid-induced gout pain models and the greatest yield. The 80% EtOH extract of S. miltiorrhiza moderately inhibited lipopolysaccharide-induced nitric oxide release from RAW 264.7 murine macrophages and exhibited outstanding yield. The mixture of optimized A. pilosa and S. miltiorrhiza extracts were evaluated for enhanced anti-nociceptive effects in gout arthritis treatment. To control extract quality, four marker compounds were determined using an HPLC-DAD method. A 1:1 mixture of A. pilosa 50 and S. miltiorrhiza 80% EtOH extracts of produced better results than when the extracts were administered individually.

References

Feb 1, 1987·Japanese Journal of Pharmacology·K MiyamotoR Koshiura
Jan 13, 2006·Nature·Fabio MartinonJürg Tschopp
Jun 17, 2006·Science·Hiroshi IkedaJürgen Sandkühler
Feb 8, 2007·Arthritis Research & Therapy·Bettina BeyreutherThomas Stöhr
Oct 21, 2009·Chemistry & Biodiversity·Liancai ZhuChao Zheng
May 9, 2012·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Soo-Hyun ParkHong-Won Suh
Feb 18, 2017·International Journal of Molecular Sciences·Set Byeol KimSoon Sung Lim

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