Anti-nociceptive effect of Faecalibacterium prausnitzii in non-inflammatory IBS-like models

Scientific Reports
Sylvie MiquelF A Carvalho

Abstract

Visceral pain and intestinal dysbiosis are associated with Irritable Bowel Syndrome (IBS), a common functional gastrointestinal disorder without available efficient therapies. In this study, a decrease of Faecalibacterium prausnitzii presence has been observed in an IBS-like rodent model induced by a neonatal maternal separation (NMS) stress. Moreover, it was investigated whether F. prausnitzii may have an impact on colonic sensitivity. The A2-165 reference strain, but not its supernatant, significantly decreased colonic hypersensitivity induced by either NMS in mice or partial restraint stress in rats. This effect was associated with a reinforcement of intestinal epithelial barrier. Thus, F. prausnitzii exhibits anti-nociceptive properties, indicating its potential to treat abdominal pain in IBS patients.

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Methods Mentioned

BETA
PCR
Flow Cytometry
ELISA

Software Mentioned

Elements
Image J
NIS
GraphPad

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