Anti-norovirus therapeutics: a patent review (2010-2015)

Expert Opinion on Therapeutic Patents
Anushka C Galasiti KankanamalageWilliam C Groutas

Abstract

Human noroviruses are the primary causative agents of acute gastroenteritis and are a pressing public health burden worldwide. There are currently no vaccines or small molecule therapeutics available for the treatment or prophylaxis of norovirus infections. An improved understanding of norovirus biology, as well as the pathogenic mechanisms underlying the disease, has provided the impetus for a range of intense exploratory drug discovery efforts targeting viral and host factors. An overview of norovirus inhibitors disclosed in the patent literature (2010-present) and Clinicaltrials.gov is presented. The review is further enriched and supplemented by recent literature reports. Seminal discoveries made in recent years, including a better understanding of the pathobiology and life cycle of norovirus, the identification and targeting of multiple viral and host factors, the advent of a replicon system and a small animal model for the preclinical evaluation of lead compounds, and the availability of high resolution X-ray crystal structures that can be utilized in structure-based drug design and lead optimization campaigns, collectively suggest that a small molecule therapeutic and prophylactic for norovirus infection is likely to eme...Continue Reading

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Citations

Dec 4, 2016·European Journal of Medicinal Chemistry·Anushka C Galasiti KankanamalageWilliam C Groutas
Jul 4, 2017·Journal of Medicinal Chemistry·Anushka C Galasiti KankanamalageKyeong-Ok Chang
Dec 26, 2018·Medicinal Research Reviews·Natalie E NetzlerPeter A White
Dec 31, 2016·European Journal of Medicinal Chemistry·Vishnu C DamalankaWilliam C Groutas
Dec 12, 2017·European Journal of Medicinal Chemistry·Vishnu C DamalankaWilliam C Groutas
Aug 29, 2021·Viruses·Louisa F Ludwig-BegallEtienne Thiry

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