Anti-Obesity effects of protopanaxdiol types of Ginsenosides isolated from the leaves of American ginseng (Panax quinquefolius L.) in mice fed with a high-fat diet

Fitoterapia
Rui LiuYi-nan Zheng

Abstract

Effects of protopanaxdiol (PDG) and protopanaxatriol (PTG) types of ginsenosides isolated from the leaves of American ginseng on porcine pancreatic lipase activity were determined in vitro. PDG inhibited the pancreatic lipase activity in a dose-dependent manner at the concentrations of 0.25-1mg/ml. It inhibited hydrolysis of about 83.2% of triolein at about 1mg/ml of PDG. However, PTG showed no inhibitory activity. Therefore, anti-obesity activity of PDG was evaluated in mice fed a high-fat diet. The results demonstrated that PDG was effective in preventing and healing obesity, fatty liver and hypertriglyceridemia in mice fed with a high-fat diet.

References

Jan 1, 1992·The American Journal of Clinical Nutrition·J B HauptmanD Hartmann
May 1, 1986·The British Journal of Nutrition·G S Sidhu, D G Oakenfull
May 21, 1986·Biochimica Et Biophysica Acta·A Larsson, C Erlanson-Albertsson
Mar 27, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·L K HanH Okuda
Oct 26, 1999·Atherosclerosis·W S Poston, J P Foreyt
Apr 29, 2000·Journal of Clinical Epidemiology·F PaccaudP Bovet
Aug 26, 2000·Current Opinion in Chemical Biology·L H Van der Ploeg
Oct 24, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·L K HanH Okuda
Aug 7, 2002·The Journal of Nutrition·Li-Kun HanYoshiyuki Kimura
Feb 1, 2003·Journal of Pharmaceutical and Biomedical Analysis·Zhang HaijiangCheng Yiyu
Feb 28, 2003·Journal of Clinical Pharmacy and Therapeutics·C I ColemanP Reddy
Mar 4, 2003·Biological & Pharmaceutical Bulletin·Hiroshi KuriharaTakaharu Tanaka
Aug 13, 2003·Bioscience, Biotechnology, and Biochemistry·Chong-Suk KwonJong-Sang Kim
Sep 12, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Seung Hwan Kim, Kyung Shin Park
Dec 4, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jing-Tian XieChun-Su Yuan
Feb 19, 2004·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·D FestiG Marchesini
Sep 11, 2004·Archives of Pharmacal Research·Se Na YunSung Hyun Chung
Nov 10, 2004·Best Practice & Research. Clinical Endocrinology & Metabolism·Masayasu KojimaKenji Kangawa
Jan 19, 2005·Journal of Pharmacological Sciences·Ji Hyun KimInsop Shim
Mar 26, 2005·Archives of Pharmacal Research·Bao Jun XuChang Keun Sung
Apr 7, 2005·BMC Complementary and Alternative Medicine·Li-Kun HanYoshiyuki Kimura
May 26, 2005·Journal of Agricultural and Food Chemistry·Masaaki NakaiYoshinobu Kiso
Jan 19, 2006·Journal of Agricultural and Food Chemistry·Kazuma YoshizumiJunji Terao
Jul 25, 2006·Physiology & Behavior·David E Cummings
Aug 29, 2006·Neuropeptides·Sarika Arora, Anubhuti
Mar 21, 2007·Journal of Agricultural and Food Chemistry·Naama KaruZohar Kerem
Oct 9, 2007·Economics and Human Biology·Cécile KnaiTim Lobstein
Oct 16, 2007·Drug Discovery Today·Rahul B Birari, Kamlesh K Bhutani
Nov 1, 2007·Biochemical and Biophysical Research Communications·Jin-Taek HwangDae Young Kwon
Dec 11, 2007·Physiology & Behavior·Annelies H C Goris, Klaas R Westerterp
Aug 23, 2008·Acta Pharmacologica Sinica·Chieh-fu ChenJun-tian Zhang
Sep 5, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Wencong LiuYixiong Feng
Dec 4, 2008·The American Journal of Chinese Medicine·Chong-Zhi Wang, Chun-Su Yuan

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Citations

Aug 4, 2011·Archives of Pharmacal Research·Kyoung-Tae LeeWan-Kyunn Whang
Jul 9, 2011·Natural Product Reports·Ilze VermaakJosias H Hamman
Apr 22, 2015·Natural Product Research·Liu HanPing-Ya Li
Aug 22, 2014·Journal of the Science of Food and Agriculture·Tae-Hyung KwonNyun-Ho Park
Jul 26, 2014·Metabolism: Clinical and Experimental·Can LiuXiao-dong Liu
Apr 16, 2014·Natural Product Research·Liu HanPing-Ya Li
Oct 25, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mariangela MarrelliGiancarlo A Statti
Apr 5, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ramgopal Mopuri, Md Shahidul Islam
Jul 8, 2020·International Journal of Molecular Sciences·Da Eun KimSung Yeon Kim
Aug 4, 2021·Journal of Agricultural and Food Chemistry·Jing ZhouWeicheng Hu

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