PMID: 8518095Jun 1, 1993Paper

Anti-OKT3 response following prophylactic treatment in paediatric kidney transplant recipients

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Patrick NiaudetL Chatenoud


The anti-OKT3 response was studied in 40 paediatric kidney transplant recipients receiving OTK3 as a prophylactic treatment in association with azathioprine and prednisone. Only 1 patient experienced a reversible acute rejection episode while receiving OKT3. OKT3 induced a rapid disappearance of CD3+ cells, but significant proportions of CD3+ cells reappeared before the end of the treatment in 14 patients. Wide variations in circulating OKT3 levels were observed and in only 50% of patients could stable circulating OKT3 levels be detected until discontinuation of treatment. Anti-OKT3 antibodies detected by the enzyme-linked immunosorbent assay (ELISA) (anti-idiotypic and anti-isotypic antibodies) developed in 91% of patients. Anti-idiotypic antibodies detected by the immunofluorescence inhibition test were found in the sera of 71% of patients, always when high titres of anti-OKT3 antibodies were detected by ELISA. As it has recently been shown that anti-idiotypic antibodies are associated with failure of subsequent OKT3 treatment, we conclude that OKT3 should be restricted to steroid-resistant rejection crises in paediatric patients.


Jan 1, 1992·Transplantation·C LegendreL Chatenoud
Jan 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·D J Norman, M Leone
May 1, 1990·The Journal of Pediatrics·M LeoneG Goldstein
Jan 1, 1990·Transplantation·T J SchroederW F Ballistreri
Aug 8, 1985·The New England Journal of Medicine·Ortho Multicenter Transplant Study Group
Feb 1, 1988·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D J NormanB Hubert
Feb 1, 1988·Transplantation·J T MayesF P Stuart
Jan 1, 1987·Nephron·L Kahana, J Baxter
Dec 1, 1981·Transplantation·A B CosimiP S Russell


Nov 29, 2011·Néphrologie & thérapeutique·Patrick Niaudet
Feb 4, 2003·Nature Reviews. Immunology·Lucienne Chatenoud
Jun 2, 2020·Frontiers in Immunology·Kristy FuConstantinos Petrovas

Related Concepts

Azathioprine sodium
Enzyme-Linked Immunosorbent Assay
Immunofluorescence Assay
Graft Rejection
Graft Survival
Immunoglobulin Isotypes
Kidney Tubular Necrosis, Acute

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