PMID: 8518095Jun 1, 1993Paper

Anti-OKT3 response following prophylactic treatment in paediatric kidney transplant recipients

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Patrick NiaudetL Chatenoud

Abstract

The anti-OKT3 response was studied in 40 paediatric kidney transplant recipients receiving OTK3 as a prophylactic treatment in association with azathioprine and prednisone. Only 1 patient experienced a reversible acute rejection episode while receiving OKT3. OKT3 induced a rapid disappearance of CD3+ cells, but significant proportions of CD3+ cells reappeared before the end of the treatment in 14 patients. Wide variations in circulating OKT3 levels were observed and in only 50% of patients could stable circulating OKT3 levels be detected until discontinuation of treatment. Anti-OKT3 antibodies detected by the enzyme-linked immunosorbent assay (ELISA) (anti-idiotypic and anti-isotypic antibodies) developed in 91% of patients. Anti-idiotypic antibodies detected by the immunofluorescence inhibition test were found in the sera of 71% of patients, always when high titres of anti-OKT3 antibodies were detected by ELISA. As it has recently been shown that anti-idiotypic antibodies are associated with failure of subsequent OKT3 treatment, we conclude that OKT3 should be restricted to steroid-resistant rejection crises in paediatric patients.

References

Jan 1, 1992·Transplantation·C LegendreL Chatenoud
Jan 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·D J Norman, M Leone
May 1, 1990·The Journal of Pediatrics·M LeoneG Goldstein
Jan 1, 1990·Transplantation·T J SchroederW F Ballistreri
Aug 8, 1985·The New England Journal of Medicine·Ortho Multicenter Transplant Study Group
Feb 1, 1988·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D J NormanB Hubert
Feb 1, 1988·Transplantation·J T MayesF P Stuart
Jan 1, 1987·Nephron·L Kahana, J Baxter
Dec 1, 1981·Transplantation·A B CosimiP S Russell

Citations

Nov 29, 2011·Néphrologie & thérapeutique·Patrick Niaudet
Feb 4, 2003·Nature Reviews. Immunology·Lucienne Chatenoud
Jun 2, 2020·Frontiers in Immunology·Kristy FuConstantinos Petrovas

Related Concepts

Teens
Anti-Antibodies
Azathioprine sodium
Enzyme-Linked Immunosorbent Assay
Immunofluorescence Assay
Graft Rejection
Graft Survival
Immunoglobulin Isotypes
Kidney Tubular Necrosis, Acute
Rectodelt

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Related Papers

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
D J Norman, M Leone
Journal of Child Health Care : for Professionals Working with Children in the Hospital and Community
F Bell
© 2021 Meta ULC. All rights reserved