Anti-osteoporosis drug use: too little, too much, or just right? The HUNT study, Norway

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
M HoffB Schei

Abstract

Use of anti-osteoporotic drugs (AODs) was examined in a Norwegian population 50-85 years. Among them with Fracture Risk Assessment Tool (FRAX) score for major osteoporotic fracture ≥ 20, 25% of the women and 17% of the men received AODs. The strongest predictors for AODs were high age in women and use of glucocorticoids among men. To examine the use of anti-osteoporotic drugs (AODs) and to identify predictors for prescriptions. Data were obtained from the Nord-Trøndelag Health Study (HUNT3) performed in 2006-2008 and the Norwegian Prescription Database, including 15,075 women and 13,386 men aged 50-85 years. Bone mineral density (BMD) in the femoral neck was measured in a subgroup of 4538 women and 2322 men. High fracture risk was defined as a FRAX score for major osteoporotic fracture (MOF) ≥ 20%; in the subgroup with BMD, high risk was in addition defined as FRAXMOF ≥ 20% or T-score ≤ - 2.5. Hazard ratios (HRs) for predictors of incident use of AODs within 2 years after HUNT3 were estimated by Cox' proportional hazards model. Among individuals with FRAX MOF ≥ 20%, 25% of the women and 17% of the men were treated with AODs. Among those with FRAX MOF < 20%, 3% and 1% were treated, respectively. In the subgroup with BMD measurem...Continue Reading

References

Nov 1, 1994·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A Kanis
Mar 23, 1995·The New England Journal of Medicine·S R CummingsT M Vogt
Jun 7, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T P Van StaaC Cooper
Jul 19, 2002·JAMA : the Journal of the American Medical Association·Jacques E RossouwUNKNOWN Writing Group for the Women's Health Initiative Investigators
May 4, 2007·The New England Journal of Medicine·Dennis M BlackUNKNOWN HORIZON Pivotal Fracture Trial
Sep 20, 2007·The New England Journal of Medicine·Kenneth W LylesUNKNOWN HORIZON Recurrent Fracture Trial
Oct 31, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E S SirisA Grauer
Oct 31, 2007·Arthritis and Rheumatism·Willem F Lems
Dec 11, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A Moayyeri
May 7, 2008·Journal of General Internal Medicine·Kathryn M RyderUNKNOWN Fracture Intervention Trial Research Group
Feb 7, 2009·Bone·John A KanisEugene McCloskey
Apr 30, 2009·Pharmacoepidemiology and Drug Safety·Svein R KjosavikSteinar Hunskaar
Jul 1, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·F BorgströmJ A Kanis
Oct 14, 2010·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Alexandra PapaioannouUNKNOWN Scientific Advisory Council of Osteoporosis Canada
Apr 13, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S Y ChengB Sobolev
Jan 13, 2012·Pharmacoepidemiology and Drug Safety·Helene M DevoldAnne Johanne Sogaard
Feb 22, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J W WastessonK Johnell
Mar 16, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisUNKNOWN IOF Working Group on Epidemiology and Quality of Life
May 1, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E S SirisS Silverman
Jul 11, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H M DevoldH E Meyer
Aug 11, 2012·International Journal of Epidemiology·S KrokstadJ Holmen
Sep 18, 2012·BMC Medical Research Methodology·Arnulf LanghammerJostein Holmen
Jan 16, 2013·Expert Opinion on Pharmacotherapy·Irene E M BultinkWillem F Lems
Mar 1, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E S SirisN B Watts
Apr 23, 2014·Nature Reviews. Endocrinology·Jane A CauleyGhada El-Hajj Fuleihan
Sep 4, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·F CosmanR Lindsay
Sep 10, 2014·Annals of Internal Medicine·Carolyn J CrandallPaul G Shekelle
Jan 1, 2014·Bone Research·Robert A Adler
Sep 4, 2015·Archives of Osteoporosis·Mari HoffBerit Schei
Jan 21, 2016·The New England Journal of Medicine·Dennis M Black, Clifford J Rosen
Oct 30, 2016·Lancet·Josef S SmolenIain B McInnes
May 11, 2016·Current Opinion in Rheumatology·Eugene V McCloskeyJohn A Kanis
Jul 13, 2016·Scandinavian Journal of Public Health
Jul 29, 2016·Archives of Osteoporosis·John A KanisUNKNOWN Advisory Board of the National Osteoporosis Guideline Group
Jul 3, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M HoffB Schei

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Citations

May 3, 2019·Current Opinion in Rheumatology·Giovanni Adami, Kenneth G Saag
Apr 15, 2020·Nature Reviews. Endocrinology·Pojchong Chotiyarnwong, Eugene V McCloskey
Apr 28, 2019·Archives of Osteoporosis·Helena SalminenE Toth-Pal
Nov 16, 2019·The Journal of Pharmacy and Pharmacology·Ying KongYang Lu
Aug 12, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J YangJ W Nieves
Jan 23, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M HoffB Schei
Jun 15, 2021·Journal of Bone and Mineral Metabolism·Satoshi SoenMakiko Kobayashi

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