Anti-Osteoporotic Effects of Polysaccharides Isolated from Persimmon Leaves via Osteoclastogenesis Inhibition

Nutrients
Youn-Hwan HwangTaesoo Kim

Abstract

Persimmon (Diospyros kaki L.f.) leaves have traditionally been used as a phytomedicine, in health beverages to treat cardiovascular and respiratory disease and to promote maternal health in East Asia. In particular, polysaccharides from persimmon are known to have anti-coagulant, anti-oxidant, and immune-stimulatory activities. However, their beneficial effects against osteoporosis have not been reported. In the present study, we investigated the anti-osteoporotic effects of polysaccharides from persimmon leaves (PLE0) using an in vivo model of ovariectomy (OVX)-induced bone loss and an in vitro system of receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation. In the OVX mouse model, PLE0 remarkably improved OVX-induced trabecular bone loss by suppressing osteoclast activity. In primary bone marrow-derived macrophages (BMMs), PLE0 dose-dependently inhibited osteoclast differentiation. In addition, PLE0 down-regulated RANKL-induced activation of mitogen-activated protein kinases (MAPKs) such as p38, ERK, and JNK resulting in suppression of nuclear factor of activated T cells cytoplasmic 1 (NFATc1) expression. Our results indicate that PLE0 has anti-osteoporotic effects in OVX-induced bone loss ...Continue Reading

References

Oct 27, 1998·Phytochemistry·U V MallavadhaniY R Rao
Aug 28, 2002·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Zeba Syed, Aliya Khan
Nov 9, 2005·The Journal of Experimental Medicine·Masataka AsagiriHiroshi Takayanagi
Dec 17, 2005·Trends in Molecular Medicine·Teiji WadaJosef M Penninger
Jan 24, 2006·International Immunopharmacology·Igor A Schepetkin, Mark T Quinn
Jul 13, 2006·Annals of the New York Academy of Sciences·F Patrick Ross
Mar 21, 2009·The Journal of Biological Chemistry·Jong-Ho LeeZang Hee Lee
Jul 7, 2009·FEBS Letters·Insun SongNacksung Kim
Feb 4, 2012·Genes & Development·Matthew S Hayden, Sankar Ghosh
Sep 11, 2012·International Journal of Biological Macromolecules·Xiaoyun LuYali Zhang
Jun 14, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Hyunil HaJin Yeul Ma
Jul 26, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hyunil HaJin Yeul Ma
Apr 4, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hyunil HaJin Yeul Ma
Aug 12, 2014·Journal of Ethnopharmacology·Yubo GuoDieter Brömme
Dec 10, 2014·Journal of Bone Metabolism·Jung Ha Kim, Nacksung Kim
Jan 1, 2014·BoneKEy Reports·Antonia Sophocleous, Aymen I Idris
Jun 21, 2015·International Journal of Biological Macromolecules·Suel-Gie LeeKyung-Tae Lee
Nov 13, 2015·Current Pharmaceutical Design·Lili WangDongwei Zhang
Dec 3, 2016·Nutrition·Nor Aijratul Asikin Mohd ShalanSuhaila Mohamed
Nov 8, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Z WangS Peng
Mar 28, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Huanhuan XuJun Sheng

❮ Previous
Next ❯

Citations

Oct 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Igor KhlusovMikhail Belousov
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ki Cheol HwangHoon Kim

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

GraphPad
Prism
DataViewer

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.