Anti-OX40 monoclonal antibody therapy in combination with radiotherapy results in therapeutic antitumor immunity to murine lung cancer

Cancer Science
Hiroshi YokouchiMasaharu Nishimura

Abstract

The therapeutic effect of agonistic anti-OX40 (CD134) monoclonal antibody (mAb) in combination with radiotherapy was evaluated in a murine lung cancer model. After intradermal transplantation of ovalbumin (OVA)-transfected Lewis lung carcinoma, C57BL/6 mice were irradiated locally with a single dose of 20 Gy in combination with an intratumoral injection of anti-OX40 mAb at 50 microg on day 4 after transplantation, which is when the major axis of the inoculated tumor reached a diameter of 7-9 mm. On days 8, 11, and 14, the tumor-bearing mice were further treated with the same dose of anti-OX40 mAb. Anti-OX40 mAb in combination with radiotherapy prolonged survival and provided greater efficacy than either single treatment against well-established tumors. An in vivo depletion study suggested that therapeutic immunity was mainly CD8(+) T-cell dependent. OX40(+)CD8(+) T cells were augmented in draining lymph nodes obtained from irradiated mice compared with those from non-irradiated mice. OVA-major histocompatibility complex tetramer(+) CD8(+) T cells had been strongly recruited to the draining lymph nodes obtained from mice treated with anti-OX40 mAb in combination with radiotherapy, and strong antigen-specific cytotoxicity was con...Continue Reading

References

Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A D WeinbergJ Shields
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·I GramagliaM Croft
Nov 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J KjaergaardS Shu
Aug 13, 2002·Current Pharmaceutical Design·Eric J Friedman
Jun 14, 2003·TheScientificWorldJournal·P Bansal-Pakala, M Croft
Feb 5, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Andrea LadányiJózsef Tímár
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pratima Bansal-PakalaMichael Croft
Jun 3, 2004·Nature Reviews. Immunology·Kazuo SugamuraAndrew D Weinberg
Oct 4, 2005·International Journal of Radiation Oncology, Biology, Physics·Sandra DemariaSilvia C Formenti
Jan 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Satoshi MurataR Todd Reilly
Jul 27, 2007·Clinical & Experimental Metastasis·Hiroshi YokouchiTakashi Nishimura

❮ Previous
Next ❯

Citations

Nov 26, 2013·The Cancer Journal·Tomasz MajWeiping Zou
Jan 5, 2010·Immunotherapy·Angela D PardeeWalter J Storkus
Jul 20, 2010·Immunotherapy·Michael J Gough, Marka R Crittenden
Feb 22, 2012·Immunotherapy·Nicole M Haynes, Mark J Smyth
Dec 17, 2014·Seminars in Oncology·Susan M Hiniker, Susan J Knox
Sep 16, 2010·International Reviews of Immunology·Adnan R KhanDavid I Pritchard
Feb 7, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Sigurd M HaldTom Donnem
Nov 16, 2010·Seminars in Oncology·Shawn M JensenBernard A Fox
Jun 25, 2008·Current Opinion in Immunology·Nicole M HaynesMark J Smyth
Aug 28, 2015·Immunotherapy·Steven N SeyedinJames W Welsh
Jan 17, 2015·Cancer Letters·Suresh J HaikerwalNicole M Haynes
Oct 7, 2014·Biochimica Et Biophysica Acta·Morgan A O'BrienPatrick F Forde
Mar 13, 2015·Frontiers in Oncology·Stefanie N LinchWilliam L Redmond
Dec 17, 2014·Frontiers in Oncology·Ralph E VatnerSilvia C Formenti
Aug 9, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ilinca PoppDan G Duda
Sep 24, 2016·Journal for Immunotherapy of Cancer·Josephine KangSilvia Formenti
Aug 30, 2016·CA: a Cancer Journal for Clinicians·Fernanda G HerreraGeorge Coukos
Dec 24, 2017·Journal of Cellular Biochemistry·Jin-Cheng WangXiao-Jie Lu
Feb 10, 2018·Immunotherapy·Maureen L AliruSunil Krishnan
Dec 19, 2018·Cancers·Shang-Jui Wang, Bruce Haffty
Jul 13, 2018·Therapeutic Advances in Vaccines and Immunotherapy·Jamie Honeychurch, Timothy M Illidge
Oct 7, 2020·Journal for Immunotherapy of Cancer·Yeonjoo ChoiJoud Hajjar
Dec 10, 2020·British Journal of Cancer·John Conibear, UNKNOWN AstraZeneca UK Limited
May 23, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sharareh NiknamJames W Welsh
Sep 4, 2020·Current Opinion in Biotechnology·Maria Ochoa de OlzaFernanda G Herrera
Mar 21, 2021·Seminars in Immunology·Mara De MartinoClaire Vanpouille-Box
May 4, 2021·Frontiers in Immunology·Renske J E van den BijgaartGosse J Adema
May 11, 2021·Frontiers in Oncology·Jonathan KhalifaElizabeth Cohen-Jonathan Moyal
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ricardo G AlvimJonathan A Coleman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cat-scratch disease

Cat-scratch disease, a relatively common infectious disease, is caused by Bartonella henselae and characterized by a fever and regional lymphadenitis. Here is the latest research.

Bartonellosis

Bartonellosis is an infection caused by bacteria in the genus Bartonella and can present as a variety of diseases depending on the organism involved. While asymptomatic infection has been reported, immunocompromised individuals are more susceptible to severe infection. Find the latest research on bartonellosis here.