Abstract
Angelica dahurica Radix is the common herbal medicine with anti-cancer activities. However, details of its anti-cancer activities are lacking. We investigated the anti-cancer effects of Angelica dahurica extract in HT-29 colon cancer cell line. Cell viability, apoptotic and necrotic activities and the mechanism of actions of the active fraction were measured. The organic extract of Angelica dahurica Radi decreased significantly the gene expression of p53, Bcl, Bax and induced apoptosis via caspase cascade and cell cycle arrest. The ethanol-ethyl acetate fraction showed anti-cancer activities in HT-29 cancer cells. A HPLC-DAD analysis of the fraction indicated the presence of Imperatorin and isoimperatorin, which are the major coumarins in the active fraction that contribute to the anti-cancer activities. This study has evaluated the ant-cancer activity of the organic extract of Angelica dahurica Radix against colon cancer cells and provided a basis of further development of the herbal extract for treatment of colon cancer.
References
Aug 1, 1990·Biopharmaceutics & Drug Disposition·G D Allen
Jun 1, 1987·Carcinogenesis·C PowerG E Neal
Feb 16, 2005·Apoptosis : an International Journal on Programmed Cell Death·E A Ostrakhovitch, M G Cherian
Apr 30, 2009·Biomedical Chromatography : BMC·Ah Yeon ParkSang Beom Han
Dec 23, 2011·Chemotherapy·Ke-wang LuoFei-yan Liu
Jul 17, 2013·Fitoterapia·Nan WangYanmin Zhang
Oct 1, 2013·Journal of Ethnopharmacology·Meng-Liang ZhuYun Luo
Dec 21, 2013·Biomedical Chromatography : BMC·Gang ZhaoSicen Wang
Jun 30, 2014·Journal of the American Society of Hypertension : JASH·Yanjun CaoLangchong He
Dec 3, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Miao LiLangchong He
Citations
Aug 18, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Alexander N Orekhov
Dec 13, 2016·Pharmaceutical Biology·Ali SenLeyla Bitis
Feb 24, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lei ZhangXiu-Wei Yang
Jan 25, 2017·Journal of Ethnopharmacology·Chenjie CaoAihua Xu
Jul 25, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yan WangWing Shing Ho
Apr 3, 2019·Biomedicines·Tinu OdeleyeJun Lu
Feb 25, 2020·Bioscience Trends·Hyun HwangboYung Hyun Choi
Mar 24, 2018·Journal of Food and Drug Analysis·Xiao-Yu WangZhan-Ying Hong
Mar 30, 2020·Journal of Separation Science·Baimei ShiXiaohui Zheng
Jun 4, 2020·Phytotherapy Research : PTR·Jue WangNan Wang
Oct 19, 2017·Molecular Medicine Reports·Jiayao OuyangDaozhang Cai
Aug 29, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pureum NohByeong Cheol Moon
Jan 3, 2020·International Journal of Molecular Medicine·Gunticha SuwanmaneeWorasak Kaewkong
Aug 8, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hyeyoon EoMyung Sook Oh
Aug 28, 2020·Free Radical Biology & Medicine·Jun GuoLiming Chen
Oct 20, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yeonsoo JoeHun Taeg Chung
Apr 27, 2021·Journal of Oncology·Yingying BaiYongxiu Yang
May 14, 2021·Frontiers in Pharmacology·Sidhartha TaritlaC Jayabaskaran
May 13, 2021·Gene·Liqiang ZhaoDaiyin Peng