Anti-oxidant and anti-cancer activities of Angelica dahurica extract via induction of apoptosis in colon cancer cells

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Yi Mei ZhengWing Shing Ho

Abstract

Angelica dahurica Radix is the common herbal medicine with anti-cancer activities. However, details of its anti-cancer activities are lacking. We investigated the anti-cancer effects of Angelica dahurica extract in HT-29 colon cancer cell line. Cell viability, apoptotic and necrotic activities and the mechanism of actions of the active fraction were measured. The organic extract of Angelica dahurica Radi decreased significantly the gene expression of p53, Bcl, Bax and induced apoptosis via caspase cascade and cell cycle arrest. The ethanol-ethyl acetate fraction showed anti-cancer activities in HT-29 cancer cells. A HPLC-DAD analysis of the fraction indicated the presence of Imperatorin and isoimperatorin, which are the major coumarins in the active fraction that contribute to the anti-cancer activities. This study has evaluated the ant-cancer activity of the organic extract of Angelica dahurica Radix against colon cancer cells and provided a basis of further development of the herbal extract for treatment of colon cancer.

References

Aug 1, 1990·Biopharmaceutics & Drug Disposition·G D Allen
Feb 16, 2005·Apoptosis : an International Journal on Programmed Cell Death·E A Ostrakhovitch, M G Cherian
Apr 30, 2009·Biomedical Chromatography : BMC·Ah Yeon ParkSang Beom Han
Jun 30, 2014·Journal of the American Society of Hypertension : JASH·Yanjun CaoLangchong He

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Citations

Aug 18, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Alexander N Orekhov
Feb 24, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lei ZhangXiu-Wei Yang
Jul 25, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yan WangWing Shing Ho
Aug 29, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pureum NohByeong Cheol Moon
Aug 8, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hyeyoon EoMyung Sook Oh
Oct 20, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yeonsoo JoeHun Taeg Chung

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