PMID: 11903743Mar 21, 2002Paper

Anti-oxidant ebselen causes the resolution of experimentally induced hepatic fibrosis in rats

Journal of Gastroenterology and Hepatology
S WasserC E Tan

Abstract

Hepatic fibrosis occurs because of injury to the liver parenchyma and biliary system. We have investigated the effect of an organic selenium anti-oxidant, ebselen, in the resolution of experimentally induced hepatic fibrosis, and evaluated its effect on various paradigms involved in hepatic fibrosis. Following pretreatment with phenobarbitone, liver fibrosis was induced in male Fischer 344 rats by using carbon tetrachloride treatment for 10 weeks. Carbon tetrachloride-treated rats were randomly assigned into two groups: (i) no ebselen; and (ii) ebselen administered for 3 weeks following a 10-week carbon tetrachloride treatment period. Normal controls were: (i) neither carbon tetrachloride nor ebselen treated; or (ii) ebselen treated for 13 weeks. Liver sections were stained with hematoxylin and eosin, Masson trichrome and stained for reticulin by using silver impregnation. Reverse transcription-polymerase chain reaction was used to analyze the steady-state levels of gene(s) involved in: (i) hepatic fibrosis, namely, transforming growth factor-beta1, procollagen I and III, tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-13; (ii) oxidative stress, namely, cytochrome P4502E1; and (iii) preneoplastic liver foci...Continue Reading

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Citations

Jul 2, 2011·Archives of Toxicology·Cristina W Nogueira, João B T Rocha
Aug 18, 2009·PloS One·Reto M BaertschigerCarmen Gonelle-Gispert
Nov 11, 2011·International Journal of Molecular Sciences·Hai Zhong HuoYan Gu
Aug 16, 2005·Journal of Pineal Research·Adolfo CruzJordi Muntané
Oct 25, 2008·Biochemical Pharmacology·Brian J Day
May 4, 2017·International Journal of Radiation Biology·Noura M Thabet, Enas M Moustafa
Dec 5, 2012·Laboratory Investigation; a Journal of Technical Methods and Pathology·Kentaro ToriumiSusumu Takekoshi
Mar 14, 2007·Journal of Applied Toxicology : JAT·Rajat Kumar DasSudin Bhattacharya
Sep 8, 2019·Hormones : International Journal of Endocrinology and Metabolism·Stergios A PolyzosLeonidas Duntas
Nov 30, 2018·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Silvia BonaNorma P Marroni
Sep 30, 2020·Environmental Science and Pollution Research International·Daifullah Al AboudRami B Kassab
Apr 2, 2021·Archives of Toxicology·Cristina W NogueiraJoão B T Rocha
Dec 9, 2004·Chemical Reviews·Cristina W NogueiraJoão B T Rocha

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