Anti-oxidant, in vitro, in vivo anti-inflammatory activity and antiproliferative activity of mefenamic acid and its metal complexes with manganese(II), cobalt(II), nickel(II), copper(II) and zinc(II)

Journal of Enzyme Inhibition and Medicinal Chemistry
Dimitra Kovala-DemertziMavroudis A Demertzis

Abstract

Some new complexes of mefenamic acid with potentially interesting biological activity are described. The complexes of mefenamic acid [Mn(mef)(2)(H(2)O)(2)], 1, [Co(mef)(2)(H(2)O)(2)], 2, [Ni(mef)(2)(H(2)O)(2)], 3, [Cu(mef)(2)(H(2)O)](2), 4 and [Zn(mef)(2)], 5, were prepared by the reaction of mefenamic acid, a potent anti-inflammatory drug with metal salts. Optical and infrared spectral data of these new complexes are reported. Monomeric six-coordinated species were isolated in the solid state for Mn(II), Ni(II) and Co(II), dimeric five-coordinated for Cu(II) and monomeric four-coordinated for Zn(II). In DMF or CHCl(3) solution the coordination number is retained and the coordinated molecules of water are replaced by solvent molecules. The anti-oxidant properties of the complexes were evaluated using the 1,1-diphenyl-2-picrylhydrazyl, DPPH, free radical scavenging assay. The scavenging activities of the complexes were measured and compared with those of the free drug and vitamin C. We have explored their ability to inhibit soybean lipoxygenase, beta-glucuronidase and trypsin- induced proteolysis. The complex [Mn(mef)(2)(H(2)O)(2)] exhibits the highest antioxidant activity and the highest inhibitory effect against the soybean li...Continue Reading

References

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Jun 1, 2000·Journal of Inorganic Biochemistry·D Kovala-Demertzi
May 20, 2003·Journal of Enzyme Inhibition and Medicinal Chemistry·Christos Kontogiorgis, Dimitra Hadjipavlou-Litina
Apr 27, 2004·Inorganic Chemistry·Saadallah RamadanPeter A Lay

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Citations

Mar 24, 2011·Future Medicinal Chemistry·Shiow Jin TanKok Hwa Lim
Jan 15, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Morteza MontazerozohoriMostafa Montazer Zohour
Jan 22, 2015·International Journal of Molecular Medicine·Jia LiuJing Gao
Jul 14, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Mohamed WehbeMarcel B Bally
Nov 16, 2018·Journal of Biochemical and Molecular Toxicology·Akif Evren ParlakMustafa Karatepe
Jun 7, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Jie FengJingyan Zhang
Jun 4, 2020·International Journal of Molecular Sciences·Olga KrasnovskayaAlexander Majouga
Jun 6, 2017·Frontiers in Microbiology·Varunkumar BhattaramKumar Venkitanarayanan
Jul 22, 2018·Metallomics : Integrated Biometal Science·Philip A Doble, George L Gabor Miklos
Jun 8, 2019·Nucleosides, Nucleotides & Nucleic Acids·Nahid ShahabadiNavid Fatahi
Nov 1, 2015·Clinical Hemorheology and Microcirculation·Bernhard HieblHarald Fischer
Nov 4, 2020·Environmental Science and Pollution Research International·Jingting HeShaojun Dong
May 13, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Rami AyoubZainul Zakaria
May 16, 2021·Bioorganic & Medicinal Chemistry Letters·Aravind R NesaragiVijay M Kumbar
Mar 25, 2014·The Journal of Physical Chemistry. B·Vanessa R R CunhaVera R L Constantino

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