PMID: 2484360Sep 1, 1988Paper

Anti-oxidant supplementation decreases TBA reactants in serum of elderly

Biological Trace Element Research
M TolonenJ Schrijver

Abstract

An "anti-oxidant cocktail" consisting of betacarotene, vitamins B6, C, E, zinc, and selenium or corresponding placebos were given for one y as daily dietary supplements to 45 elderly residents of a nursing home. Initially, the serum TBA reactant levels were higher (2.7 +/- 0.7 mumol/L) than those of an ad hoc control group of healthy younger adults (2.3 +/- 0.6 mumol/L), p less than 0.01. After three mo supplementation, the levels among the verum elderly had decreased to 2.2 +/- 0.6 mumol/L, and they remained at this lower level until the end of the study period, whereas the placebo group showed no change. A significant inverse correlation (r = -0.428, p less than 0.01) existed between the concentrations of serum TBA reactants and whole blood selenium (B-Se), but only B-Se levels above 200 micrograms/L were associated with a decrease in serum lipid peroxides. Serum alpha-tocopherol concentration also correlated inversely with serum TBA reactants but this correlation (r = -0.273, p less than 0.76) was not as strong as that of B-Se. Deficient vitamin B6 status, in biochemical terms, was observed in 25% of the elderly; a daily supplement of 2 mg B6 fully cured all cases of deficiency. The verum group improved slightly in several p...Continue Reading

References

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Citations

Jan 1, 1991·Biological Trace Element Research·J Clausen
Mar 1, 1995·Social Science & Medicine·J F EmardD Gauvreau
Mar 2, 1992·Neuroscience Letters·J A MolinaR Codoceo
Oct 1, 1992·Free Radical Biology & Medicine·H EsterbauerG Jürgens
Nov 7, 2001·Clinical and Experimental Dermatology·M Podda, M Grundmann-Kollmann
May 12, 2001·The British Journal of Nutrition·G F Combs
May 1, 1996·International Journal of Food Sciences and Nutrition·I F Benzie
Jan 1, 1991·Annals of Medicine·H EsterbauerH Rabl
Jul 1, 1996·Journal of the American Geriatrics Society·S B Kritchevsky, M F Muldoon
Jul 1, 1996·Journal of the American Geriatrics Society·A MezzettiR Fellin

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