Anti-oxidative activity of an aqueous suspension of commercial preparation of the mushroom Coprinus comatus.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Mira PopovićV Jakovljevic

Abstract

In this study the effects of an aqueous suspension of a commercial preparation of the mushroom Coprinus comatus on oxidative stress induced in rats by alloxane and carbon tetrachloride was examined. The effects were estimated from changes in the biochemical parameters (xanthine oxidase, glutathione peroxidase and catalase activity, reduced glutathione content, and extent of lipid peroxidation) of liver homogenate as well as histological changes in the liver of the rats treated with alloxane and carbon tetrachloride. Two screening doses of alloxane sufficient to induce diabetes in rats did not have any significant effect on the examined biochemical parameters of liver homogenate or on the cytoarchitectonics of liver cross-sections. Treatment with carbon tetrachloride resulted in a significant increase in the intensity of lipid peroxidation and peroxydasis activity, as well as with decrease in catalase activity. Certain changes in liver cross sections were detected, such is lymphocyte infiltration of dilated sinusoid capillaries. Administration of Coprinus comatus suspension thus showed antioxidative potential, evidenced by an increase of antioxidative status of liver homogenate and prevention of histological changes in liver cro...Continue Reading

References

Oct 11, 1976·Biochimica Et Biophysica Acta·D T ChiuA L Tappel
Sep 24, 2004·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Eisuke KumeKunio Doi
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Sep 30, 2010·Phytotherapy Research : PTR·A SaboV Jakovljevic

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Citations

Jun 8, 2013·Chemico-biological Interactions·Xuekang YangDahai Hu
Apr 26, 2012·BMC Complementary and Alternative Medicine·Jun RenJian-You Guo
Jul 26, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andréia Assunço SoaresRosane Marina Peralta
Nov 3, 2016·Biological Trace Element Research·Hacer DoganFikret Karatas
May 29, 2020·Phytotherapy Research : PTR·Patryk NowakowskiKatarzyna Socha

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