Anti-oxidative and anti-inflammatory effects of lipoic acid in rat liver

Postȩpy higieny i medycyny doświadczalnej
Anna GoracaBeata Skibska

Abstract

Lipopolysaccharide (LPS) is a key inflammatory component of Gram-negative bacteria, which after entering the systemic circulation contributes to the development of septic hepatic failure. The aim of this study was to evaluate the effects of alpha lipoic acid (LA) on oxidative stress parameters and inflammation in endotoxemic rat liver. Male Wistar rats were divided into 4 groups, each group consisting of 8 animals. Group I received saline and served as a control, Group II received a single dose of LA (60 mg/kg i.v.), Group III received lipopolysaccharide (LPS) (15 mg/kg i.v.), and Group IV received LPS (15 mg/kg i.v.) and 30 min later received LA (60 mg/kg i.v.). Five hours after LPS or LA administration, the animals were sacrificed and the liver was isolated for measurements of levels of thiobarbituric acid reactive substances (TBARS), hydrogen peroxide (H2O2), total sulfhydryl groups (-SH), total glutathione (tGSH) and reduced glutathione (GSH). Injection of LPS caused a significant increase in liver TBARS and H2O2 levels and a significant decrease in levels of -SH groups, tGSH and GSH. LPS-treated rats also showed an increase in TNF-α and IL-6 levels and edema in the liver. The administration of LA to endotoxemic rats signif...Continue Reading

Citations

Feb 4, 2014·European Journal of Pharmacology·Shimaa M ElshazlyWaleed Barakat
Oct 9, 2016·Clinical and Experimental Pharmacology & Physiology·Dilek ÖzbeyliÖzgür Kasımay Çakır
Jan 11, 2017·Oxidative Medicine and Cellular Longevity·Sha LiYibin Feng
Feb 16, 2019·International Journal of Food Sciences and Nutrition·M P ValdecantosJ A Martínez
Nov 23, 2021·Journal of Dietary Supplements·Cristiane Simões Coelho Britto RamosMauricio Alves Chagas

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