Anti-oxidative and anti-inflammatory effects of Rosa Mosqueta oil supplementation in rat liver ischemia-reperfusion

Food & Function
Camila G DossiG Tapia

Abstract

Ischemia-reperfusion (IR) is a deleterious condition associated with liver transplantation or resection that involves pro-oxidant and pro-inflammatory mechanisms. Considering that Rosa Mosqueta (RM) oil composition is rich in protective components such as α-linolenic acid (ALA) and tocopherols, we studied the effects of RM oil supplementation given prior to an IR protocol. Male Sprague-Dawley rats receiving RM oil (0.4 mL d-1) for 21 days were subjected to 1 h of ischemia followed by 20 h reperfusion. Parameters of liver injury (serum transaminases, histology), oxidative stress [liver contents of protein carbonyls, thiobarbituric acid reactants, Nrf2 activity and its target mRNA expression of heme oxygenase-1 (HO-1) and NADPH-quinone oxidoreductase-1 (NQO-1)] and inflammation [nuclear factor-κB (NF-κB) and its target mRNA expression of tumor necrosis factor-α (TNF-α) and interleukine-1β (IL-1β)] were studied. RM oil increased liver ALA and its derived EPA and DHA fatty acids' contents, with enhancement in those of α- and γ-tocopherols. IR induced inflammatory liver injury, with enhancement in serum transaminases, oxidative stress-related parameters with reduced Nrf2 signaling, and higher pro-inflammatory cytokines, indexes that...Continue Reading

References

Jan 1, 1988·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·R J NautaA Butterfield
Jun 1, 1986·The Journal of Experimental Medicine·C A DinarelloJ V O'Connor
Jan 1, 1994·Methods in Enzymology·A Z Reznick, L Packer
Jun 30, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K SoltysB Koneru
Oct 3, 2001·Journal of Hepatology·M Parola, G Robino
May 2, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Qing Jiang, Bruce N Ames
May 31, 2003·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Hartmut Jaeschke
Mar 1, 1959·Journal of Clinical Pathology·L HENRY
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER
Jul 30, 2004·Proceedings of the National Academy of Sciences of the United States of America·Riccardo BertiniFrancesco Colotta
Sep 24, 2004·The Journal of Biological Chemistry·Petra KempnáJean-Marc Zingg
Jun 15, 2005·Revista médica de Chile·Pamela Romanque ULuis A Videla
Oct 28, 2005·Journal of Zhejiang University. Science. B·E GruysS J Koopmans
Jan 6, 2006·Archives of Pharmacal Research·Woo-Yong Lee, Sun-Mee Lee
Apr 25, 2006·Free Radical Biology & Medicine·Gladys TapiaLuis A Videla
Apr 25, 2006·Surgery Today·Dimitrios GiakoustidisDimitrios Takoudas
Nov 16, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Manfred BilzerAlexander L Gerbes
Nov 28, 2006·The Journal of Biological Chemistry·Ling GaoMichael L Freeman
Dec 26, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Virginia FernándezLuis A Videla
Dec 26, 2006·Journal of Hepatology·Rita CariniEmanuele Albano
Jan 6, 2007·Bioresource Technology·Daniel FrancoMaría José Núñez
Jan 30, 2007·Pharmacology·Ender DulunduGoksel Sener
Feb 24, 2007·Molecular Aspects of Medicine·Elke ReiterStephan Christen
Feb 23, 2008·Free Radical Biology & Medicine·Virginia FernándezLuis A Videla
Dec 17, 2008·Atherosclerosis·Derek J Hausenloy, Derek M Yellon
Sep 28, 2010·The Journal of Surgical Research·Wilmar de GraafThomas M van Gulik
Dec 6, 2011·The Journal of Nutritional Biochemistry·Marcelo MardonesGladys Tapia
May 9, 2012·World Journal of Hepatology·Virginia FernándezLuis A Videla
May 23, 2012·Cytokine & Growth Factor Reviews·Rowan F van GolenMichal Heger
Feb 26, 2013·Free Radical Biology & Medicine·Suryakant K NitureAnil K Jaiswal

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