Anti-oxidative effect of AST-120 on kidney injury after myocardial infarction

British Journal of Pharmacology
Hideki FujiiShinichi Nishi

Abstract

Chronic kidney disease (CKD) is a crucial risk factor for cardiovascular disease (CVD), and combined CKD and CVD further increases morbidity and mortality. Here, we investigated effects of AST-120 on oxidative stress and kidney injury using a model of myocardial infarction (MI) in rats. At 10 weeks, male spontaneously hypertensive rats (SHR) were divided into three groups: SHR (n = 6), MI (n = 8) and MI + AST-120 (n = 8). AST-120 administration was started at 11 weeks after MI. At 18 weeks, the rats were killed, and blood and urine, mRNA expression and renal histological analyses were performed. Echocardiography was performed before and after MI. At 18 weeks, the BP was significantly lower in the MI and MI+AST-120 groups than in the SHR group. Elevated levels of indoxyl sulfate (IS), one of the uremic toxins, in serum and urine were reduced by AST-120 treatment, compared with the MI group. Markers of oxidative stress in urine and serum biomarkers of kidney injury were decreased in the MI+AST-120 group compared with the other two groups. Renal expression of mRNAs for kidney injury related-markers were decreased in the MI+AST-120 group, compared with the MI group. In vitro data also supported the influence of IS on kidney injury....Continue Reading

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Citations

May 11, 2019·International Journal of Molecular Sciences·Simona AdessoStefania Marzocco
May 19, 2018·Toxins·Hideki FujiiMasafumi Fukagawa
May 22, 2018·Journal of Atherosclerosis and Thrombosis·Ippei WatanabeToshisuke Morita
Sep 29, 2020·Journal of Atherosclerosis and Thrombosis·Hideki Fujii

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