Anti-Oxidative Effect of Myrtenal in Prevention and Treatment of Colon Cancer Induced by 1, 2-Dimethyl Hydrazine (DMH) in Experimental Animals

Biomolecules & Therapeutics
Booupathy LokeshkumarMaruthaiveeran Periyasamy Balasubramanian

Abstract

Colon cancer is considered as the precarious forms of cancer in many developed countries, with few to no symptoms; the tumor is often diagnosed in the later stages of cancer. Monoterpenes are a major part of plant essential oils found largely in fruits, vegetables and herbs. The cellular and molecular activities show therapeutic progression that may reduce the risk of developing cancer by modulating the factors responsible for colon carcinogenesis. Colon cancer was induced with DMH with a dose of (20 mg/Kg/body weight) for 15 weeks by subcutaneous injection once in a week. Myrtenal treatment was started with (230 mg/Kg/body weight) by intragastric administration, one week prior to DMH induction and continued till the experimental period of 30 weeks. The Invivo results exhibit the elevated antioxidant and lipid peroxidation levels in DMH treated animals. The Histopathological analysis of colon tissues well supported the biochemical alterations and inevitably proves the protective role of Myrtenal. Treatment with myrtenal to cancer bearing animals resulted in a remarkable increase in the inherent antioxidants and excellent modulation in the morphological and physiological nature of the colon tissue. It is thus concluded that myrt...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jun 1, 1972·Analytical Biochemistry·A K Sinha
Feb 9, 1973·Science·J T RotruckW G Hoekstra
Jul 8, 1969·Biochimica Et Biophysica Acta·G E StaalC Veeger
Jan 1, 1984·Methods in Enzymology·I D Desai
Mar 20, 1999·The Journal of Nutrition·P L Crowell
Feb 26, 2000·Carcinogenesis·L J Marnett
Mar 10, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F Marks, G Fürstenberger
Jan 5, 2002·International Journal of Cancer. Journal International Du Cancer·Paola PisaniD Maxwell Parkin
Aug 2, 2003·Molecular Aspects of Medicine·Neven Zarkovic
Mar 11, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mairi MacarthurEmad M El-Omar
Oct 22, 2004·Nutrition Journal·Michael S Donaldson
Mar 8, 2005·Medical Oncology·Faruk TasErkan Topuz
Mar 31, 2005·Journal of Agricultural and Food Chemistry·Ravi JoshiTulsi Mukherjee
Apr 12, 2005·Environmental Science & Technology·Juan CasadoMaría Isabel Galán
Sep 14, 2006·Journal of Agricultural and Food Chemistry·Katrin R StrehleJürgen Popp
May 16, 2008·Biomedical and Environmental Sciences : BES·Archana Kumari, Poonam Kakkar
Dec 17, 2008·Nutrition Research·Kettelin A ArbosAlmeriane M Weffort-Santos
Jun 1, 2000·Nutrition Research Reviews·G G DuthieJ A Kyle
Aug 4, 2009·Chemical Reviews·Juliano Lemos BicasGláucia Maria Pastore
Aug 10, 2010·Cancer Investigation·Robert C G MartinDavid W Hein
Nov 3, 2010·Clinics in Colon and Rectal Surgery·Fatima A Haggar, Robin P Boushey
Jan 5, 2011·Frontiers in Bioscience (Landmark Edition)·Anupam BishayeeMarjorie Perloff
Aug 25, 2011·Current Opinion in Plant Biology·Nobuhiro SuzukiRon Mittler
Jul 6, 2012·Molecular and Cellular Biochemistry·Lingaiah Hari BabuMaruthaiveeran Periyasamy Balasubramanian

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Citations

Jan 7, 2017·World Journal of Gastroenterology : WJG·Wei-Zhong ShengWei-Dong Gao
Apr 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Odette ConcepciónClaudio A Jiménez
May 23, 2020·Toxicology Research·Karthikkumar VenkatachalamRajasekar Ponnaiyan

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