Anti-oxidative effect of resveratrol on aluminum induced toxicity in rat cerebral tissue

Bratislavské lekárske listy
M M H ZakariaB M Saleh

Abstract

The direct protective effects of resveratrol against oxidative stress have been demonstrated in neuroglial cells, the mechanisms of these effects are not fully understood. The aim of this research was to study the effect of resveratrol on AL induced cerebral injury in rat. We divided the groups as follows with 10 animals each: a) Group I - served as control receiving normal drinking water and diet ad libitum. b) Group II - animals were administered aluminum at a dose level of 100 mg/kg body weight for a period of 6 weeks daily through oral gavage. c) Group III - animals were administered aluminum at a dose level of 100 mg/kg body weight and resveratrol at a dose of 10 mg/kg body weight intraperitoneally for a period of 6 weeks daily. After 6 weeks rats were anesthetized and decapitated. Brains were removed immediately and frozen in liquid nitrogenRESULTS: The levels of SOD and GPx antioxidant enzymes were decreased in all of the groups receiving aluminium, but it was less severe in resveratrol treated group. SOD and GPx levels in aluminium + resveratrol group were higher than in the aluminum group (p < 0.05). MDA level, as an index of lipid peroxidation, increased significantly in all of the groups receiving aluminium. MDA leve...Continue Reading

Citations

Aug 5, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Carmen Peña-BautistaConsuelo Cháfer-Pericás
Oct 4, 2020·Environmental Toxicology and Pharmacology·Fatma M El-DemerdashAnsam B Al Mhanna
Nov 7, 2021·Biological Trace Element Research·Maha LokmanNabil A El-Yamany

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