Anti-p97/VCP antibodies: an autoantibody marker for a subset of primary biliary cirrhosis patients with milder disease?

Scandinavian Journal of Immunology
K MiyachiM J Fritzler

Abstract

We previously reported that 12.5% of primary biliary cirrhosis (PBC) sera reacted with a 95 kDa cytosol protein (p95c) that was subsequently identified as a p97/valosin-containing protein (VCP). The clinical features and course of the six anti-p97/VCP-positive PBC patients with Scheuer's stage 1 and 2 liver biopsies were monitored for an average of 15 years. This group was compared with 50 PBC patients that did not have detectable anti-VCP. Autoantibodies to a full-length recombinant p97/VCP were assayed by immunoprecipitation. All six PBC patients with anti-VCP had antibodies to the mitochondrial pyruvate dehydrogenase complex-E2 antigen as measured by an addressable laser bead immunoassay. The first was a male with no evidence of liver failure that died of cerebral infarction at the age of 85. The second was a 73-year-old female with Hashimoto's thyroiditis who has remained clinically stable without ursodeoxycolic acid (UDCA) treatment. Although the third had no HCV antibodies, he developed hepatocellular carcinoma at the age of 76 and died of renal failure at 78. The fourth was a 50-year-old female who remained clinically stable during follow-up and the fifth with Hashimoto's thyroiditis and stable liver function following U...Continue Reading

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Citations

Aug 3, 2010·World Journal of Gastroenterology : WJG·Chao-Jun HuXuan Zhang
Mar 15, 2014·World Journal of Gastroenterology : WJG·Satoshi YamagiwaYutaka Aoyagi
Nov 26, 2015·Clinics in Liver Disease·Simona MarzoratiAna Lleo
Aug 23, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elvire BeleokenEric Ballot
Nov 26, 2010·Clinical and Experimental Immunology·L M StintonM J Fritzler
Mar 4, 2008·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·K MiyachiM J Fritzler
Apr 27, 2019·Frontiers in Immunology·Adam AmlaniMarvin J Fritzler

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