Anti-Parkinson Potential of Silymarin: Mechanistic Insight and Therapeutic Standing

Frontiers in Pharmacology
Hammad Ullah, Haroon Khan

Abstract

Parkinson's disease (PD) involves aggregation of α-synuclein and progressive loss of dopaminergic neurons. Pathogenesis of PD may also be related to one's genetic background. PD is most common among geriatric population and approximately 1-2% of population suffers over age 65 years. Currently no successful therapies are in practice for the management of PD and available therapies tend to decrease the symptoms of PD only. Furthermore, these are associated with diverse range of adverse effects profile. The neuroprotective effects of polyphenols are widely studied and documented. Among phytochemicals, silymarin is one of the most widely used flavonoids because of its extensive therapeutic properties and has been indicated in pathological conditions of prostate, CNS, lungs, skin, liver, and pancreas. Silymarin is a mixture of flavonolignans (silybin, isosilybin, and silychristin), small amount of flavonoids (taxifolin), fatty acids, and other polyphenolic compounds extracted from the dried fruit of Silybum marianum and is clinically used for hepatoprotective effects since ancient times. Neuroprotective effects of silymarin have been studied in various models of neurological disorders such as Alzheimer's disease, PD, and cerebral is...Continue Reading

References

Jun 13, 2002·Journal of Molecular Neuroscience : MN·Smita KitturDilip S Kittur
Apr 1, 2003·Annals of Neurology·Olivier RascolJean-Louis Montastruc
May 5, 2005·Experimental Neurology·Andreas Hald, Julie Lotharius
Nov 1, 2005·Journal of Viral Hepatitis·K E MayerS S Lee
Apr 14, 2006·Current Medicinal Chemistry·Fernando A Crocenzi, Marcelo G Roma
Apr 26, 2006·Experimental Biology and Medicine·Meharvan SinghJames W Simpkins
May 23, 2006·Lancet Neurology·Lonneke M L de Lau, Monique M B Breteler
Oct 21, 2006·Journal of Neuroinflammation·David A LoefflerStephanie B Conant
Feb 20, 2007·Current Medicinal Chemistry·Radek GazákVladimír Kren
Mar 3, 2007·Archives of Pharmacal Research·Jong Soo WooSang-Cheol Chi
Jun 6, 2007·Integrative Cancer Therapies·Janice Post-WhiteKara M Kelly
May 13, 2008·Cancer Letters·Kumaraguruparan Ramasamy, Rajesh Agarwal
Aug 7, 2008·Biotechnology Advances·Adam Matkowski
Aug 12, 2008·Journal of Neurochemistry·Changyoun Kim, Seung-Jae Lee
Sep 2, 2008·Holistic Nursing Practice·Stephanie Maxine Ross
Sep 20, 2008·Journal of Neurology·Guido AlvesJan Petter Larsen
Jun 19, 2009·Mini Reviews in Medicinal Chemistry·J M MatésJ Márquez
Aug 4, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·F GalhardiD M Barros
May 7, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ahmad JowaedUllrich Wüllner
May 12, 2010·Cold Spring Harbor Perspectives in Biology·Toby Lawrence
May 25, 2010·Nature Medicine·Jose A ObesoGlenda Halliday
May 27, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Yassine ChtourouNajiba Zeghal
Jun 1, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jessica WagonerStephen J Polyak
Oct 13, 2010·Biochemical and Biophysical Research Communications·Marina YamadaMasao Kaneki
Oct 13, 2010·Neuroimmunomodulation·Dario Domenico LofrumentoMaria Antonietta Panaro
Oct 23, 2010·Journal of Pineal Research·Naveen Kumar SinghalMahendra Pratap Singh
Aug 11, 2011·Recent Patents on Inflammation & Allergy Drug Discovery·Laura MarzocchellaRoberto Bei
Jan 11, 2012·Current Pharmaceutical Design·Maria Antonietta Panaro, Antonia Cianciulli
Jul 26, 2012·Oxidative Medicine and Cellular Longevity·Abdelkader BasliTristan Richard
Sep 4, 2012·Molecular Neurobiology·Maria XilouriLeonidas Stefanis
Dec 4, 2012·Free Radical Biology & Medicine·Michael H YanXiongwei Zhu
Dec 4, 2012·Nutrients·William M JohnsonJohn J Mieyal
Dec 6, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Stephen J PolyakJean-Michel Pawlotsky
Jun 12, 2013·Frontiers in Bioscience (Landmark Edition)·Monica BenvenutoRoberto Bei
Jul 11, 2013·Oxidative Medicine and Cellular Longevity·Khushwant S Bhullar, H P Vasantha Rupasinghe

❮ Previous
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Citations

May 10, 2019·Phytotherapy Research : PTR·Vahid SoleimaniGholamreza Karimi
May 10, 2020·Antioxidants·Antonia DiukendjievaIlza Pajeva
Jun 2, 2020·Critical Reviews in Food Science and Nutrition·Haroon KhanSeyed Mohammad Nabavi
Mar 7, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Fernanda Caetano Camini, Daniela Caldeira Costa
Jan 8, 2020·Biomolecules·Haroon KhanEsra Küpeli Akkol
Apr 30, 2020·International Journal of Molecular Sciences·Erteng JiaQinyu Ge
Jan 16, 2020·Antioxidants·Rui F M Silva, Lea Pogačnik
Feb 16, 2020·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Haroon KhanAnupam Bishayee
Jun 30, 2019·Integrative Biology : Quantitative Biosciences From Nano to Macro·Khaled YoussefPouya Rezai
Jan 17, 2020·Nutrients·Marcella RealeAngelo Cichelli
Aug 3, 2019·Seminars in Cancer Biology·Haroon KhanMohammad Amjad Kamal
Feb 6, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Muhammad Shoaib TahirWei Zhang
Oct 19, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Haroon KhanEsra Kupeli Akkol
Mar 12, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zelma FaisalMiklós Poór
May 7, 2019·Autoimmunity Reviews·Haroon KhanMichael Aschner

❮ Previous
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