Anti-PD-1 Therapy Response Predicted by the Combination of Exosomal PD-L1 and CD28

Frontiers in Oncology
Chaoxu ZhangXiujuan Qu

Abstract

Anti-PD-1 therapy has been approved for cancer treatment. However, the response rate is unsatisfactory. The expression of PD-L1 in tumor tissues is unreliable to predict the treatment response. Recent studies have suggested that exosomal PD-L1 not only exerts immunosuppressive effects but also plays a significant role in the development of tumor microenvironment. Thus, the present study aims to investigate exosomal PD-L1 in improving its predictive value and efficacy. A total of 44 patients of advanced tumors of several types, treated with anti-PD-1 therapy, were enrolled. Exosomes were collected and purified from plasma. The exosomal PD-L1 was detected with ELISA. The cytokines were measured with the MILLIPLEX magnetic bead assay. Compared to the responders, exosomal PD-L1 of the non-responders was significantly higher than that of the responders (P = 0.010) before the treatment. Concurrently, exosomal PD-L1 and tumor burden decreased when the therapy was effective. And, the baseline expression of CD28 was higher in the responders than that in the non-responders (P = 0.005). Univariate and multivariate analyses validated with 1,000 times bootstrapping suggested that high exosomal PD-L1 and low CD28 expressions were negative fa...Continue Reading

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Citations

Aug 28, 2020·International Journal of Molecular Sciences·Haoyao SunWei-Qun Ding
Oct 20, 2020·Frontiers in Oncology·Tao FanJie He
Feb 26, 2021·Journal of Immunology Research·Sergio Ayala-MarJosé González-Valdez
Jun 3, 2021·International Journal of Molecular Sciences·Siddarth KannanEmyr Yosef Bakker
Jun 27, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Honggang YingXueli Bai
Nov 27, 2021·Journal of Cellular Physiology·Seyed Z RasihashemiParisa Lotfinejad

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Methods Mentioned

BETA
Blood
blood collection
flow cytometry
enzyme-linked immunosorbent assay
electron microscopy
biopsy

Software Mentioned

R
tile
SPSS Statistics
Milliplex Analyst
Nanosight

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