Anti-peroxidative and anti-hyperlipidemic nature of Ulva lactuca crude polysaccharide on D-galactosamine induced hepatitis in rats

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Arumugam SathivelThiruvengadam Devaki

Abstract

To find whether pretreatment of Ulva lactuca polysaccharide (ULP) extract could be effective against D-Galactosamine (500 mg/kg body weight, i.p.) induced anomaly in rat. Serum total cholesterol (TC), triglycerides (TG), free fatty acid (FFA), phospholipids (PL), high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), tissue lipoperoxides (LPO), hepatic protein thiols, non-enzymatic anti-oxidants glutathione (GSH) and vitamins (E and C) were examined using spectrophotometer. The ultra structural changes of liver during D-Galactosamine and protection offered by ULP were examined by electron microscopy. Seaweed histology and chemical composition of polysaccharides in seaweed were examined. Alcian blue staining showed the presence of sulphated polysaccharide with total sugar (65.4%), sulphate (17.4%), and uronic acid (17.2%) content. D-Galactosamine intoxicated rats showed significant (p<0.01) liver damage with acute aberration in serum lipid profile, hepatic protein thiols and tissue non-enzymatic anti-oxidants. Assorted deposits of lipid droplets and abnormal appearance of mitochondria was observed in electron microscopy study. Rats pretreated with ULP (30 mg/kg body weight/day/for 21 ...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Nov 1, 1969·Analytical Biochemistry·Y KawaiK Anno
Nov 2, 1983·European Journal of Biochemistry·O SireJ Nordmann
Apr 1, 1980·Journal of Clinical Pharmacology·S T OmayeH E Sauberlich
Mar 1, 1996·Atherosclerosis·P J Barter, K A Rye
Apr 1, 1959·Journal of Neurochemistry·M LEESS CARR
Oct 7, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yu PengzhanLi Pengcheng
Feb 26, 2004·Applied Biochemistry and Biotechnology·Shin HirayamaYoshiro Okami
Aug 19, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Arumugam SathivelThiruvengadam Devaki

❮ Previous
Next ❯

Citations

Apr 18, 2013·Asian Pacific Journal of Tropical Biomedicine·Sheik Abdulazeez Sheriff, Thiruvengadam Devaki
Feb 13, 2013·Antioxidants & Redox Signaling·Eun-Jung Park, John M Pezzuto
May 20, 2015·Marine Drugs·Maria Filomena de Jesus RaposoRui Manuel Santos Costa de Morais
Mar 22, 2014·Critical Reviews in Biotechnology·Elena Geta PopaManuela Estima Gomes
Dec 3, 2014·International Journal of Biological Macromolecules·Ping ShaoPeilong Sun
Nov 26, 2011·International Journal of Biological Macromolecules·Huimin QiQuanbin Zhang
Jan 24, 2015·Annales pharmaceutiques françaises·M El WahidiT Bamhaoud
Mar 9, 2010·Bioscience, Biotechnology, and Biochemistry·Toshiyuki AkachiKimio Sugiyama
Jun 14, 2016·Tissue & Cell·Neriman ColakogluGozde Parlak
Aug 6, 2016·Archives of Physiology and Biochemistry·Suat TekinBayram Yilmaz
Aug 19, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Arumugam SathivelThiruvengadam Devaki
Jul 12, 2017·Archives of Physiology and Biochemistry·Intissar KammounIbtissem Ben Amara
Aug 30, 2019·Current Pharmaceutical Design·Soraya SajadimajdRoja Rahimi
Aug 22, 2018·Frontiers in Pharmacology·Celso AlvesRui Pedrosa
May 1, 2019·Comprehensive Reviews in Food Science and Food Safety·Bhakti Tanna, Avinash Mishra
Aug 2, 2017·Journal of Proteome Research·Sheik Abdulazeez SheriffHoracio Pérez-Sánchez

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.