Abstract
To investigate the association of antibodies to β2-glycoprotein I (anti-β2GPI), cardiolipin (ACA), phosphatidylserine (anti-PS) and prothrombin (anti-PT) with recurrent spontaneous miscarriage (RSM). Case-control study involving 277 RSM cases and 288 controls: autoantibody levels were measured by ELISA. Differences between cases and controls were analyzed by nonparametric Mann-Whitney test, and logistic regression was used in analyzing the association of autoantibodies with RSM. Anti-PS IgG, ACA IgM and IgG, and anti-PT IgM were significantly associated with RSM risk, and differential antibody association was noted according to BMI and primary and secondary RSM. Higher prevalence of elevated anti-PS IgG was seen in cases, with the strongest risk above the 99th percentile. For ACA IgM, 28 cases (10.1%) and 5 controls (1.7%) were positive, with increasing OR for increasing cut-off points, which was significant at antibody titers >99th percentile. For ACA IgG, 101 cases (36.5%) and 13 controls (4.5%) were positive, with graded increase in OR for increasing cut-off points, which was significant at titers >90th percentile (maximal at titers >99th percentile). For anti-PT, 23 cases (12.0%) and 9 controls (6.1%) were positive, with in...Continue Reading
References
Apr 1, 1996·British Journal of Haematology·T A BrightonC N Chesterman
Jan 1, 1997·Biology of Reproduction·H KatsuragawaN S Rote
Jun 9, 1999·Fertility and Sterility·T SugiT Makino
May 18, 2001·Seminars in Reproductive Medicine·D W Cramer, L A Wise
Sep 14, 2001·American Journal of Reproductive Immunology : AJRI·A TsutsumiT Koike
Nov 8, 2001·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·L HeilmannS Kuse
Jun 5, 2002·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·M A BrownJ M Moutquin
Jul 12, 2002·The New England Journal of Medicine·Phillip Periman
Dec 7, 2002·Obstetrics and Gynecology·Raj Rai, Lesley Regan
Jul 19, 2003·Blood·Jean-Christophe GrisMichel Dauzat
Jun 24, 2004·American Journal of Reproductive Immunology : AJRI·I MaraiY Shoenfeld
Oct 28, 2004·Thrombosis Research·Roger Abramino LevySilvia Pierangeli
Mar 8, 2005·Best Practice & Research. Clinical Obstetrics & Gynaecology·T Flint Porter, James R Scott
Aug 24, 2005·Seminars in Perinatology·Michael J PaidasYale S Arkel
Jan 20, 2006·Journal of Thrombosis and Haemostasis : JTH·S MiyakisS A Krilis
Oct 6, 2007·Clinical Reviews in Allergy & Immunology·H J A Carp, Y Shoenfeld
Aug 19, 2008·Autoimmunity Reviews·Pier Luigi Meroni, Yehuda Shoenfeld
Nov 26, 2008·Fertility and Sterility·UNKNOWN Practice Committee of tAmerican Society for Reproductive Medicine
Mar 20, 2009·Fertility and Sterility·Jaume Alijotas-ReigMiquel Vilardell-Tarres
May 15, 2009·Fertility and Sterility·Mostafa MetwallyTin Chiu Li
Sep 16, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Troy D JaskowskiAnne E Tebo
Nov 10, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Bi-Yun ZhangZi-Neng Wang
Dec 17, 2009·Hematology·Wendy Lim
Dec 25, 2009·Journal of Autoimmunity·Andrea T BorchersM Eric Gershwin
Aug 14, 2010·Journal of Thrombosis and Haemostasis : JTH·D M CohnR G Farquharson
Nov 23, 2010·American Journal of Reproductive Immunology : AJRI·Mai S SaterWassim Y Almawi
Dec 18, 2010·Expert Review of Clinical Immunology·Amolak S BansalMeen-Yau Thum
Apr 7, 2011·Journal of Reproductive Immunology·Mai S SaterWassim Y Almawi
Citations
Aug 29, 2014·Arthritis Research & Therapy·Pier Luigi MeroniMaria Gerosa
Mar 22, 2014·Autoimmunity Reviews·Guilherme R de JesusD Ware Branch
Apr 12, 2016·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Angad SinghManju Puri
Aug 1, 2012·Orvosi hetilap·Klára Gadó, Gyula Domján
Jun 17, 2015·Journal of Immunology Research·Polona ŽigonAleš Ambrožič
Jun 13, 2015·Journal of Immunology Research·M SénantM-A Dragon-Durey
Jul 17, 2016·Best Practice & Research. Clinical Rheumatology·M KhamashtaA Tincani
Sep 18, 2014·Lupus·A E Tebo
Sep 26, 2014·Lupus·H KhogeerT Owaidah
Jan 29, 2016·HLA : Immune Response Genetics·X ChenY Zeng
Mar 17, 2018·American Journal of Clinical Pathology·Amaris CastanonEmilio B Gonzalez
Sep 27, 2018·Clinical Rheumatology·Arvind GanapatiDebashish Danda
Feb 15, 2021·Human Immunology·Raazia TasadduqAbdul-Rauf Shakoori
Jul 19, 2021·Gene·Meruyert AbdukassimovaWassim Y Almawi