Oct 15, 2019

Anti-Phospho-Tau Gene Therapy for Chronic Traumatic Encephalopathy

Human Gene Therapy
Chester Bittencourt SacramentoRonald G Crystal

Abstract

Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disorder caused by repetitive trauma to the central nervous system (CNS) suffered by soldiers, contact sport athletes, and civilians following accident-related trauma. CTE is a CNS tauopathy, with trauma-induced inflammation leading to accumulation of hyperphosphorylated forms of the microtubule-binding protein Tau (pTau), resulting in neurofibrillary tangles and progressive loss of neurons. At present, there are no therapies to treat CTE. We hypothesized that direct CNS administration of an adeno-associated virus (AAV) vector coding for an anti-pTau antibody would generate sufficient levels of anti-pTau in the CNS to suppress pTau accumulation thus interrupting the pathogenic process. Using a serotype AAVrh.10 gene transfer vector coding for a monoclonal antibody directed against pTau, we demonstrate the feasibility of this strategy in a murine CTE model in which pTau accumulation was elicited by repeated traumatic brain injury (TBI) using a closed cortical impact procedure over 5 days. Direct delivery of AAVrh.10 expression vectors coding for either of the two different anti-pTau antibodies to the hippocampus of these TBI mice significantly reduced pTau...Continue Reading

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Citations

Mentioned in this Paper

Monoclonal Antibodies
Tauopathies
Neurofibrillary Degeneration (Morphologic Abnormality)
Neurons
Molecular_function
Administration Procedure
Gene Transfer, Horizontal
Genetic Vectors
Tau Proteins
Inflammation

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