Anti-phospholipase A₂ receptor antibodies in recurrent membranous nephropathy

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
A KattahF C Fervenza

Abstract

About 70% of patients with primary membranous nephropathy (MN) have circulating anti-phospholipase A2 receptor (PLA2R) antibodies that correlate with disease activity, but their predictive value in post-transplant (Tx) recurrent MN is uncertain. We evaluated 26 patients, 18 with recurrent MN and 8 without recurrence, with serial post-Tx serum samples and renal biopsies to determine if patients with pre-Tx anti-PLA2R are at increased risk of recurrence as compared to seronegative patients and to determine if post-Tx changes in anti-PLA2R correspond to the clinical course. In the recurrent group, 10/17 patients had anti-PLA2R at the time of Tx versus 2/7 patients in the nonrecurrent group. The positive predictive value of pre-Tx anti-PLA2R for recurrence was 83%, while the negative predictive value was 42%. Persistence or reappearance of post-Tx anti-PLA2R was associated with increasing proteinuria and resistant disease in 6/18 cases; little or no proteinuria occurred in cases with pre-Tx anti-PLA2R and biopsy evidence of recurrence in which the antibodies resolved with standard immunosuppression. Some cases with positive pre-Tx anti-PLA2R were seronegative at the time of recurrence. In conclusion, patients with positive pre-Tx a...Continue Reading

References

Mar 1, 1988·Kidney International·J V DonadioC P Chu
Jul 8, 1993·The New England Journal of Medicine·A SchieppatiG Remuzzi
Jun 26, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·K O NetzerM Weber
Jul 12, 2002·The New England Journal of Medicine·Esther M BrigantiSteven J Chadban
Aug 19, 2003·Seminars in Nephrology·Rajiv D PoduvalBasit Javaid
May 1, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T S DabadeF G Cosio
Feb 5, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Z M El-ZoghbyF G Cosio
Jul 3, 2009·The New England Journal of Medicine·Laurence H BeckDavid J Salant
Oct 23, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ziad M El-ZoghbyF G Cosio
Feb 27, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Ben SprangersCheryl L Kunis
Sep 8, 2010·The New England Journal of Medicine·Rolf StahlKai Fechner
Feb 18, 2011·The New England Journal of Medicine·Hanna Debiec, Pierre Ronco
Apr 9, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Julia M HofstraDavid J Salant
May 14, 2011·Journal of the American Society of Nephrology : JASN·Weisong QinZhihong Liu
Jun 3, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Elion HoxhaRolf A K Stahl
Aug 11, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H DebiecP Ronco
Nov 5, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M B Andrésdóttir, J F M Wetzels
Jan 12, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·E F RodriguezL D Cornell
Dec 1, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Christopher P LarsenPatrick D Walker
Dec 12, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Barbora SvobodovaHanna Debiec
Jan 19, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Cheng Cheng HuangTibor Nadasdy
Jun 14, 2014·American Journal of Clinical Pathology·Sjoerd A M E G TimmermansUNKNOWN Limburg Renal Registry
Jul 27, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Barbara Seitz-PolskiVincent L M Esnault

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Citations

Apr 21, 2016·The Medical Clinics of North America·Ryan J GoldbergPraveen Kandula
Apr 7, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rebecca C Graves, Richard N Fine
Apr 18, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jean M FrancisDavid J Salant
Feb 29, 2016·Lancet·Jürgen Floege, Kerstin Amann
Nov 18, 2015·BioMed Research International·Bogdan ObriscaGabriel Mircescu
Mar 29, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A G KattahF C Fervenza
Nov 1, 2016·Journal of the American Society of Nephrology : JASN·An S De VrieseFernando C Fervenza
Jul 4, 2017·Nature Reviews. Nephrology·Piero RuggenentiGiuseppe Remuzzi
Apr 10, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Daniel Cattran, Paul Brenchley
Jan 10, 2018·World Journal of Transplantation·Fedaey AbbasAhmed Halawa
Jul 4, 2018·Nephrology·Izumi YamamotoTakashi Yokoo
May 28, 2017·Clinical Journal of the American Society of Nephrology : CJASN·William G Couser
May 3, 2019·Current Opinion in Nephrology and Hypertension·Agnieszka PozdzikFrancis Corazza
Aug 24, 2017·Current Opinion in Nephrology and Hypertension·Christopher D Blosser, Roy D Bloom
Jun 15, 2017·Transplantation·Puneet Sood, Sundaram Hariharan
Aug 17, 2018·International Journal of Nephrology·Artur Q B da SilvaGianna Mastroianni-Kirsztajn
Aug 23, 2020·International Journal of Molecular Sciences·Barbara InfanteGiovanni Stallone
Sep 15, 2017·BioMed Research International·Andreas KronbichlerJae Il Shin
Nov 3, 2016·Clinical Transplantation·Edward J Filippone, John L Farber
Sep 14, 2018·BMC Nephrology·Audrey UffingLeonardo V Riella
Jun 28, 2019·Frontiers in Immunology·Patrizia PasseriniPiergiorgio Messa
Oct 4, 2020·Current Opinion in Nephrology and Hypertension·Chukwuma A ChukwuPhilip A Kalra
Mar 23, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Chethan M PuttarajappaSundaram Hariharan
Apr 13, 2021·Indian Journal of Nephrology·Shane A BobartAndrew Bentall
Oct 2, 2021·Nature Reviews. Disease Primers·Pierre RoncoJack Wetzels

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