PMID: 2502650Jul 3, 1989Paper

Anti-phospholipid antibody with recurrent venous thromboembolism and severe autoimmune thrombocytopenia

Klinische Wochenschrift
J KienastJ van de Loo

Abstract

A 51 year-old man with a history of deep venous thromboses and recurrent pulmonary embolism on long-term anticoagulant treatment was admitted to our department because of insidious onset thrombocytopenia. He had neither a history nor clinical signs of abnormal bleeding. On admission, the platelet count was reduced to 21 x 10(9)/l, platelet associated IgG was increased, and bone marrow specimens showed megakaryocytic hyperplasia. Platelet survival was slightly shortened with enhanced platelet sequestration in a normal size spleen. Laboratory evaluation after discontinuation of anticoagulant treatment revealed persisting prolongation of both the prothrombin time and the activated partial thromboplastin time which could be attributed to the presence of a lupus-type circulating anticoagulant. Further relevant laboratory findings included an elevated titer of IgG anti-cardiolipin antibodies and a reduced euglobulin clot lysis activity after venous occlusion due to increased plasminogen activator inhibitor activity. In recent years, it has become apparent that a striking correlation exists between the presence of antibodies to phospholipids and thromboembolic disease and immune thrombocytopenia respectively. The present case report o...Continue Reading

References

Jan 1, 1988·Annual Review of Medicine·E N HarrisG R Hughes
Oct 1, 1985·Seminars in Thrombosis and Hemostasis·R A Marlar
Feb 1, 1985·British Journal of Haematology·E N HarrisG R Hughes

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Citations

Jun 30, 1997·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·E Berg-DammerD Kühne

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