Anti-Photoaging Effects of Angelica acutiloba Root Ethanol Extract in Human Dermal Fibroblasts

Toxicological Research
Min Ah ParkYoung Chul Kim

Abstract

The effects that ultraviolet rays elicit on collagen synthesis and degradation are the most common causes of wrinkle formation and photo-aging in skin. The objectives of this study were to evaluate the effects of Angelica acutiloba root ethanol extract (AAEE) to promote collagen synthesis and inhibit collagen degradation in human dermal fibroblasts. By examining total polyphenol and flavonoid contents, electron donating ability, radical scavenging activity, and superoxide dismutase-like activity, we found that AAEE exhibited fairly good antioxidant activity. Treatment with AAEE significantly increased type I procollagen production by cultured fibroblasts, as well as reduced ultraviolet-induced matrix metalloproteinase-1 (MMP-1) expression and MMP-2 activity in a dose-dependent manner (p < 0.05). In addition, AAEE significantly increased TIMP-1 mRNA expression (p < 0.05), although without an associated dose-dependent increase in TIMP-1 protein expression. In summary, we suggest that AAEE may be a potentially effective agent for the prevention or alleviation of skin-wrinkle formation induced by ultraviolet rays.

References

Jun 15, 1987·European Journal of Biochemistry·L Bruckner-TudermanP Bruckner
Aug 1, 1995·The Journal of Investigative Dermatology·H S TalwarJ J Voorhees
Aug 15, 1997·Microscopy Research and Technique·I Pasquali-Ronchetti, M Baccarani-Contri
Feb 5, 1998·Experimental Dermatology·V M Kähäri, U Saarialho-Kere
Oct 24, 1998·Progress in Biophysics and Molecular Biology·N Borkakoti
Jun 25, 1999·Free Radical Biology & Medicine·R ReC Rice-Evans
Mar 10, 2000·Biochimica Et Biophysica Acta·K BrewH Nagase
Jun 1, 2000·Experimental Gerontology·K Scharffetter-KochanekM Wlaschek
Nov 1, 2001·Annual Review of Cell and Developmental Biology·M D Sternlicht, Z Werb
Nov 13, 2001·The Journal of Biological Chemistry·Gloria A Di LulloJames D San Antonio
Aug 21, 2003·Burns : Journal of the International Society for Burn Injuries·Mohan R K DasuDavid N Herndon
Mar 24, 2004·Micron : the International Research and Review Journal for Microscopy·Margaret Tzaphlidou
Aug 2, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Mi-Sun KimJin Ho Chung
Jan 18, 2006·Matrix Biology : Journal of the International Society for Matrix Biology·Yoshihiro MimuraKunihiko Tamaki
Nov 17, 2006·The Journal of Investigative Dermatology·David R Bickers, Mohammad Athar
Aug 21, 2009·Cell and Tissue Research·Marion K Gordon, Rita A Hahn
Dec 13, 2012·International Journal of Molecular Medicine·Bo-Mi HwangYoung-Rae Lee
Feb 16, 2016·Toxicological Research·Bi Gyeon HaYoung Chul Kim

❮ Previous
Next ❯

Citations

Jan 18, 2018·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Jeum-Nam Kim, Byung-Mu Lee
Oct 20, 2017·Laboratory animal research·Jun-Won YunByeong-Cheol Kang
Apr 3, 2019·International Journal of Molecular Sciences·Mei Jing PiaoJin Won Hyun
Jul 21, 2020·Oxidative Medicine and Cellular Longevity·Hee-Jeong ChoiSang-Han Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.