Anti-programmed cell death-1 therapy-associated bullous disorders: a systematic review of the literature

Melanoma Research
Cathy Yunjia ZhaoPablo Fernandez-Peñas

Abstract

Bullous disorders are rare adverse events associated with anti-programmed cell death-1 (anti-PD1) therapy. This paper presents two new cases of bullous disorders under anti-PD1 therapy and systematically reviewed the literature to foster a better understanding of the presentation and pathogenesis of bullous disorders under anti-PD1. A systematic review of the literature was completed using MEDLINE, Embase, PubMed and LILACS databases. We identified 29 cases of bullous disorders under anti-PD1 therapy, including our two new cases. This includes 18 cases of bullous pemphigoid (BP), five cases of toxic epidermal necrolysis (TEN)/Stevens-Johnson syndrome (SJS) spectrum, one case of erythema multiforme (EM), four cases of bullous lichenoid reactions and one case of vesiculobullous eczema. In BP, blistering occurred by a median of 23 weeks after anti-PD1 therapy initiation and is often preceded by a prodrome, which lasts for a median of 9.5 weeks. Limbs and trunk were the most frequently involved body sites. Most cases (76%) achieved remission. In TEN/SJS/EM, blistering was usually preceded by a prodrome of interface dermatitis that lasted for a median of 1.5 weeks. Most cases (80%) died from either TEN/SJS or disease progression. Bu...Continue Reading

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Citations

Jul 25, 2019·Dermatologic Therapy·Carlos Cuenca-BarralesRicardo Ruiz-Villaverde
Feb 14, 2020·International Journal of Dermatology·Nolan J MaloneyScott Worswick
Mar 21, 2020·Journal of Cutaneous Pathology·Lisa M MorrisIlana S Rosman
Apr 4, 2021·Journal of Clinical Medicine·Emi DikaSimone Ribero
Mar 31, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·C JuzotG Quéreux

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Methods Mentioned

BETA
biopsy
enzyme-linked immunosorbent essay
ELISA
biopsies

Software Mentioned

SPSS

Related Concepts

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