PMID: 26320493Sep 1, 2015Paper

Anti-proliferative Activities of Metallic Nanoparticles in an in Vitro Breast Cancer Model

Asian Pacific Journal of Cancer Prevention : APJCP
Samah A LoutfySerag Eldin I Elbehairi

Abstract

To investigate effect of metallic nanoparticles, silver (AgNPs) and gold nanoparticles (AuNPs) as antitumor treatment in vitro against human breast cancer cells (MCF-7) and their associated mechanisms. This could provide new class of engineered nanoparticles with desired physicochemical properties and may present newer approaches for therapeutic modalities to breast cancer in women. A human breast cancer cell line (MCF-7) was used as a model of cells. Metallic nanoparticles were characterized using UV-visible spectra and transmission electron microscopy (TEM). Cytotoxic effects of metallic nanoparticles on MCF-7 cells were followed by colorimetric SRB cell viability assays, microscopy, and cellular uptake. Nature of cell death was further investigated by DNA analysis and flow cytometry. Treatment of MCF-7 with different concentrations of 5-10nm diameter of AgNPs inhibited cell viability in a dose-dependent manner, with IC50 value of 6.28μM, whereas treatment of MCF-7 with different concentrations of 13-15nm diameter of AuNPs inhibited cell viability in a dose-dependent manner, with IC50 value of 14.48μM. Treatment of cells with a IC50 concentration of AgNPs generated progressive accumulation of cells in the S phase of the cell ...Continue Reading

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Citations

Mar 6, 2017·Advances in Colloid and Interface Science·Ignác Capek
Dec 12, 2018·Future Medicinal Chemistry·Ahmed M AbdellahRehab M Amin
Nov 28, 2019·Environmental Science and Pollution Research International·Syed Zameer Ahmed KhaderPaulpandi Manickam
May 10, 2017·Nanoscale Research Letters·Igor ShmarakovAnna Eremenko
Aug 16, 2017·Nanoscale Research Letters·Elena PavlovichAnatoliy Goltsev
Jul 14, 2018·International Journal of Molecular Sciences·Shana J CameronWilliam G Willmore
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sergio A Bernal-ChávezGerardo Leyva-Gómez
Aug 8, 2021·International Journal of Molecular Sciences·Mariana VassalMaria de Lourdes Pereira
Aug 28, 2021·International Journal of Molecular Sciences·Valentina BordoniLuigi Bagella

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