Anti-proliferative and anti-invasive effects of ferulic acid in TT medullary thyroid cancer cells interacting with URG4/URGCP

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Yavuz DodurgaN Lale Şatıroğlu-Tufan

Abstract

Ferulic acid (4-hydroxy-3-methoxycinnamic acid; FA), a common dietary plant phenolic compound, is abundant in fruits and vegetables. The aim of present study is to investigate the effects of FA on cell cycle, apoptosis, invasion, migration, and colony formation in the TT medullary thyroid cancer cell line. The effect of FA on cell viability was determined by using CellTiter-Glo assay. IC50 dose in the TT cells was detected as 150 μM. URG4/URGCP (upregulated gene-4/upregulator of cell proliferation) is a novel gene in full-length mRNA of 3.607 kb located on 7p13. It was determined that FA caused a decrease in the expression of novel gene URG4/URGCP, CCND1, CDK4, CDK6, BCL2, MMP2, and MMP9, a significant increase in the expression of p53, PARP, PUMA, NOXA, BAX, BID, CASP3, CASP9, and TIMP1 genes in TT human thyroid cancer cell line by using real-time PCR. It was found that FA in TT cells suppressed invasion, migration, and colony formation by using matrigel invasion chamber, wound healing, and colony formation assay, respectively. In conclusion, it is thought that FA indicates anticarcinogenesis activity by affecting cell cycle arrest, apoptosis, invasion, migration, and colony formation on TT cells.

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Citations

Feb 27, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sumit GhoshParames C Sil
Dec 16, 2017·Journal of Cellular Biochemistry·Faiza Abdul RashidAmmad Ahmad Farooqi
Feb 8, 2020·Biomolecules·Mariam AbotalebDietrich Büsselberg
Jan 27, 2019·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Figen Aslan, Ayla Solmaz Avcıkurt
Jun 20, 2020·Journal of Orthopaedic Surgery and Research·Yayun LiuMaolin He
Nov 4, 2016·Molecular and Cellular Biochemistry·Esra Tokay, Feray Kockar
Jul 4, 2019·Current Pharmaceutical Design·Ana PaunkovGerasimos P Sykiotis
Jul 25, 2019·European Journal of Medicinal Chemistry·Shijie ZhaoYumeng Wei

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Related Papers

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Veli ÇıtışlıN Lale Şatıroğlu-Tufan
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Canan EroğluYavuz Dodurga
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Hsin-Yu FangBing-Hung Chen
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