Anti-proliferative diterpenes from Dacrycarpus imbricatus

Natural Product Research
Nguyen Thanh TamTrinh Thi Thuy

Abstract

A new diterpene, cassipouryl hexadecanoate (2), in addition to the cassipourol (1) and four terpenes (3-6) were isolated from the twigs and leaves of Dacrycarpus imbricatus (Blume) de Laub. The structures of the two monocyclic diterpenes (1, 2), were elucidated on the basic of 1D and 2D NMR spectroscopic data and compared with the literature. These two monocyclic diterpenes (1, 2) were tested for their anti-proliferative activity on acute myeloid leukemia (OCI-AML) cells. The results showed that 1 had significantly anti-proliferative activity whereas 2 was weakly active.

References

Oct 2, 2003·Chemical & Pharmaceutical Bulletin·Consolacion Y RagasaJohn A Rideout
Feb 28, 2006·Journal of Natural Products·V S Prakash ChaturvedulaDavid G I Kingston
Sep 15, 2007·Phytochemistry·Ana M L SecaIgnacio A Jimenez
Feb 27, 2017·Asian Pacific Journal of Tropical Medicine·Trinh Thi ThuyDomenico V Delfino
Nov 9, 2017·Natural Product Research·Zuofa YangYegao Chen

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Methods Mentioned

BETA
NMR
flow cytometry
column chromatography

Software Mentioned

Cell Fit

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