Anti-proliferative effect of camellianin A in Adinandra nitida leaves and its apoptotic induction in human Hep G2 and MCF-7 cells.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Han GaoYongsheng Chen

Abstract

Leaves of Adinandra nitida constitute a kind of flavonoid-rich plant food. In this study, camellianin A, the main flavonoid in the leaves of Adinandra nitida,was prepared and identified by high performance liquid chromatography-photodiode array detector-electrospray ionization mass spectrometry (HPLC-PDA-ESI/MS). In the anticancer assay, it was found camellianin A could inhibit the proliferation of the human hepatocellular liver carcinoma Hep G2 and human breast adenocarcinoma MCF-7 cell lines in a dose-dependent manner and induce the significant increase of the G0/G1 cell population. After treated by camellianin A, phosphatidylserine of Hep G2 and MCF-7 cells could translocate significantly to the surface of the membrane. The increase of an early apoptotic population of Hep G2 and MCF-7 cells was observed. It was concluded that camellianin A not only affected the progress of the cell cycle, but also induced cells to enter into apoptosis.

References

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Citations

Jun 29, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Yunliang ZhengJianzhong ShenTu
Dec 11, 2014·Journal of Agricultural and Food Chemistry·Yongsheng ChenRui-Hai Liu

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Methods Mentioned

BETA
FACS
flow cyctometry
fluorescence-activated cell sorter

Software Mentioned

Empower

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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