Anti-proliferative effect of toremifene and tamoxifen on estrogen receptor-lacking anaplastic thyroid carcinoma cell lines

Biological & Pharmaceutical Bulletin
T KishinoI Sugawara

Abstract

The antitumor effects of toremifene were studied in vitro using 10 anaplastic thyroid carcinoma cell lines and were compared with those of tamoxifen. The antitumor effect of toremifene was dose-dependent and the IC50 values for these cell lines ranged 20.1-58.5 microM. Although the cell lines expressed multidrug resistance gene mRNA, multidrug resistance-associated protein gene mRNA and insulin-like growth factor-1 (IGF-1) receptor mRNA to various degrees, nine of them lacked estrogen receptor expression as evaluated by immunocytochemistry. These data indicate that toremifene, as well as tamoxifen, is cytolytic at relatively high doses for multidrug-resistant anaplastic thyroid carcinoma cell lines.

Citations

Oct 18, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hwa-Young SonMasao Hirose
Oct 17, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Natsu FujikiShin-ichi Hayashi
Jan 13, 2015·Pathology Oncology Research : POR·Rehab Allah Ahmed, Engy M Aboelnaga

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