Anti-proliferative, pro-apoptotic and anti-oxidative activity of Lactobacillus and Bifidobacterium strains: A review of mechanisms and therapeutic perspectives

Critical Reviews in Food Science and Nutrition
Adriana NowakJanusz Błasiak

Abstract

Lactobacillus and Bifidobacterium strains, their isolated constituents and substances that they secrete exert various anti-cancer actions, resulting from their anti-proliferative, pro-apoptotic and anti-oxidant properties. They can express and secrete anti-oxidant enzymes, bind reactive oxygen species, release small molecular weight anti-oxidants and chelate transition metals, preventing detrimental actions of many carcinogens. Lactobacillus and Bifidobacterium can interact with proteins regulating the cell cycle inhibiting proliferation of cancer cells, which often are intrinsically resistant to apoptosis. Lactobacilli and bifidobacteria can break this resistance through activation of pro-caspases and downregulation of the anti-apoptotic Bcl-2 and upregulation of pro-apoptotic Bax proteins. Anti-cancer effects of these bacteria can be also associated with their multi-pathways action in the microbiota. However, exact mechanism of their anti-cancer action is poorly known and needs further studies, which are justified by the important role of these bacteria in cancer biology as well as their potential preventive and therapeutic use.

References

Jan 23, 1998·JPEN. Journal of Parenteral and Enteral Nutrition·V MedinaF González
Nov 5, 1999·Applied and Environmental Microbiology·T PessiE Isolauri
Nov 24, 1999·Journal of Agricultural and Food Chemistry·M Y Lin, C L Yen
Jul 8, 2000·Microbes and Infection·K Hirayama, J Rafter
Feb 18, 2003·Journal of Applied Microbiology·H AnnukM Mikelsaar
May 13, 2006·Journal of Carcinogenesis·Gulam Waris, Haseeb Ahsan
Sep 19, 2006·The International Journal of Biochemistry & Cell Biology·Marian ValkoJoshua Telser
Oct 19, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Verena Juliana KollerSiegfried Knasmüller
Apr 22, 2009·Microbial Ecology in Health and Disease·Marika Mikelsaar, Mihkel Zilmer
May 30, 2009·Nature Reviews. Drug Discovery·Dunyaporn TrachoothamPeng Huang
Aug 1, 2009·The International Journal of Biochemistry & Cell Biology·Kazuei Igarashi, Keiko Kashiwagi
Jun 26, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Gerardo NardoneAntonio Colantuoni
Aug 14, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ludmila KhailovaBohuslav Dvorak
Sep 3, 2010·Biotechnology Advances·S BadelP Michaud
Dec 18, 2010·Free Radical Biology & Medicine·Justin L Rains, Sushil K Jain
May 2, 2012·Molecular Biology Reports·Anju A AchuthanSunita Grover
Nov 28, 2012·BMC Surgery·Mario UccelloAntonio Biondi
Nov 28, 2012·Gut Pathogens·Sunita GroverVirender Kumar Batish
Jan 4, 2013·Nutrition Reviews·Manoj KumarBirbal Singh
Jul 31, 2013·PloS One·Blanda Di LucciaAlessandra Pollice
Sep 11, 2013·Postȩpy higieny i medycyny doświadczalnej·Ewa WasilewskaMariola E Pijagin
Jan 28, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Linda VongPhilip M Sherman
Feb 7, 2014·Critical Reviews in Food Science and Nutrition·Rabia Ashraf, Nagendra P Shah
Apr 4, 2014·BioMed Research International·Kou-Gi ShyuDuen-Suey Chou
Jul 1, 2014·World Journal of Gastroenterology : WJG·Li ZhongMihai Covasa

❮ Previous
Next ❯

Citations

May 28, 2019·Frontiers in Immunology·Luca MagistrelliCristoforo Comi
Jan 22, 2020·Digestive Diseases and Sciences·Poliana Guiomar de Ameida BrasielReggiani Vilela Gonçalves
May 8, 2019·American Journal of Primatology·Celeste J BrownLarry J Forney
Oct 10, 2020·Expert Opinion on Biological Therapy·Abdul Arif KhanZakir Khan
Dec 30, 2020·Ecotoxicology and Environmental Safety·Guijie ChenHuimei Cai
Dec 22, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Aja BadgeleyAshakumary Lakshmikuttyamma
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anna OniszczukJolanta Szymańska
Apr 4, 2021·Biomedicines·Mariarosaria CuozzoRoberto Russo
Oct 17, 2020·Neural Regeneration Research·Vanessa CastelliAnnamaria Cimini
May 14, 2021·Cancer Cell International·Zeinab FaghfooriAhmad Yari Khosroushahi
Dec 3, 2021·Journal of Agricultural and Food Chemistry·Yong ZhangXiangyuan Wan

❮ Previous
Next ❯

Methods Mentioned

BETA
histone acetylation

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.