PMID: 26320443Sep 1, 2015Paper

Anti-Proliferative Properties of Cornus mass Fruit in Different Human Cancer Cells

Asian Pacific Journal of Cancer Prevention : APJCP
Bahman YousefiRana Jahanban-Esfahlan

Abstract

There is a long standing interest in natural compounds especially those with a high polyphenolic content and high scavenging activity for hazardous free radicals. Cornus mas (CM) fruit is well known for its antioxidant activities; however, its toxicity against human cancers needs to be addressed. Here, we investigated selective anticancer effects of CM on different human cancer cells. A hydro-alcoholic extract of CM (HECM) was prepared and total phenolic content (TPC) and total flavonoid content (TFC) were determined by colorimetric assays. Antioxidant activity was assessed with respectto DPPH radical scavenging. MTT assays were used to evaluate the cytotoxicity of different doses of CM (0, 5, 20, 100, 250, 500, 1000 μg/ ml) towards A549 (lung non small cell cancer), MCF-7 (breast adenocarcinoma), SKOV3 (ovarian cancer) and PC-3 (prostate adenocarcinoma) cells. Significant (P<0.05) or very significant (P<0.001) differences were observed in comparison to negative controls at all tested doses (5-1000 μg/ml). In all cancer cells, HECM reduced the cell viability to values below 26%, even at the lowest doses. In all cases, IC50 was obtained at doses below 5μg/ml. The mean growth inhibition was 81.8%, 81.9%, 81.6% and 79.3% in SKOV3,...Continue Reading

References

Jan 23, 2002·Japanese Journal of Cancer Research : Gann·Nobuko Shindo-OkadaYasuhiro Nagamachi
Apr 18, 2002·Journal of Agricultural and Food Chemistry·Navindra P SeeramMuraleedharan G Nair

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Citations

Apr 5, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Khaled SeidiMehran Mesgari Abbasi
Oct 5, 2017·Journal of Nephropathology·Saeid Heidari-SoreshjaniAli Saeedi-Boroujeni
Aug 7, 2017·Journal of Complementary & Integrative Medicine·Fatemeh Hosseinpour-JaghdaniMahmoud Rafieian-Kopaei
Oct 15, 2018·Journal of Cellular Physiology·Aynaz MihanfarBahman Yousefi
Sep 8, 2019·Antioxidants·Angeliki Tiptiri-KourpetiKaterina Chlichlia
Sep 14, 2018·Frontiers in Pharmacology·Monika E Czerwińska, Matthias F Melzig
Mar 27, 2019·Oxidative Medicine and Cellular Longevity·Jan LietavaOlga Pechanova
Jan 12, 2020·Photodiagnosis and Photodynamic Therapy·István-Péter LaszlóAdriana Muresan
Nov 5, 2019·Biochemical Pharmacology·Maryam MajidiniaAmin Safa

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