PMID: 26320439Sep 1, 2015Paper

Anti Proliferative Properties of Melissa officinalis in Different Human Cancer Cells

Asian Pacific Journal of Cancer Prevention : APJCP
Akram Jahanban-EsfahlanRana Jahanban-Esfahlan

Abstract

Medicinal plants, especially examples rich in polyphenolic compounds, have been suggested to be chemopreventive on account of their antioxidative properties. Melissa officinalis L. (MO), an aromatic and medicinal plant, is well known in thios context. However, toxicity against cancer cells has not been fully studied. Here, we investigated the selective anticancer effects of an MO extract (MOE) in different human cancer cells. a hydro-alcoholic extract of MO was prepared and total phenolic content (TPC) and total flavonoid content (TFC) were determined by colorimetric assays. Antioxidant activity was determined by DPPH radical scavenging activity. MTT assays were used to evaluate cytotoxicity of different doses of MOE (0, 5, 20, 100, 250, 500, 1000 μg/ml) towards A549 (lung non small cell cancer cells), MCF-7 (breast adenocarcinoma), SKOV3 (ovarian cancer cells), and PC-3 (prostate adenocarcinoma) cells. Significant (P<0.01) or very significant (P<0.0001) differences were observed in comparison to negative controls at all tested doses (5-1000 μg/ml). In all cancer cells, MOE reduced the cell viability to values below 33%, even at the lowest doses. In all cases, IC50 values were below 5μg/ml. The mean growth inhibition was 73.1%,...Continue Reading

References

Mar 24, 2000·Invasion & Metastasis·O H Sanchez-SweatmanG Singh
Jan 23, 2002·Japanese Journal of Cancer Research : Gann·Nobuko Shindo-OkadaYasuhiro Nagamachi
May 15, 2004·The Journal of Pharmacy and Pharmacology·Allyne Carvalho de SousaCerli Rocha Gattass
Jan 15, 2008·European Journal of Medicinal Chemistry·Simone C B GnoattoSafa Moslemi
Oct 4, 2011·Plant Foods for Human Nutrition·Manuel Alejandro EncaladaMaría Isabel Calvo
Sep 4, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Serpil Unver SaraydinMustafa Turan
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Aug 16, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Mehran Mesgari AbbasiRana Jahanban- Esfahlan
Oct 24, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Mehran Mesgari AbbasiRana Jahanban-Esfahlan

❮ Previous
Next ❯

Citations

Nov 28, 2017·Current Medicinal Chemistry·Anastasia V BalakirevaAndrey A Zamyatnin
May 1, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Roxana GhiulaiLaurentiu Sima
Jul 6, 2019·BioMed Research International·Ashanti Concepcion Uscanga-PalomequeCristina Rodríguez-Padilla
Apr 5, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Khaled SeidiMehran Mesgari Abbasi
Jun 12, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Elena-Alina MoacăŞtefana Avram

❮ Previous
Next ❯

Related Concepts

Related Papers

Asian Pacific Journal of Cancer Prevention : APJCP
Sina ModaeinamaRana Jahanban-Esfahlan
Plant Foods for Human Nutrition
Manuel Alejandro EncaladaMaría Isabel Calvo
Journal of Acupuncture and Meridian Studies
Surendra Kumar Sharma, Ajay Pal Singh
© 2021 Meta ULC. All rights reserved