Anti-protein and anti-bacterial behavior of amphiphilic silicones

Polymer Chemistry
Melissa L HawkinsMelissa A Grunlan

Abstract

Silicones with improved water-driven surface hydrophilicity and anti-biofouling behavior were achieved when bulk-modified with poly(ethylene oxide) (PEO) -silane amphiphiles of varying siloxane tether length: α-(EtO)3Si-(CH2)2-oligodimethylsiloxane m -block-poly(ethylene oxide)8-OCH3 (m = 0, 4, 13, 17, 24, and 30). A PEO8-silane [α-(EtO)3Si-(CH2)3-PEO8-OCH3] served as a conventional PEO-silane control. To examine anti-biofouling behavior in the absence versus presence of water-driven surface restructuring, the amphiphiles and control were surface-grafted onto silicon wafers and used to bulk-modify a medical-grade silicone, respectively. While the surface-grafted PEO-control exhibited superior protein resistance, it failed to appreciably restructure to the surface-water interface of bulk-modified silicone and thus led to poor protein resistance. In contrast, the PEO-silane amphiphiles, while less protein-resistant when surface-grafted onto silicon wafers, rapidly and substantially restructured in bulk-modified silicone, exhibiting superior hydrophilicity and protein resistance. A reduction of biofilm for several strains of bacteria and a fungus was observed for silicones modified with PEO-silane amphiphiles. Longer siloxane te...Continue Reading

References

Jan 1, 1995·Journal of Biomaterials Science. Polymer Edition·J M AndersonT L Bonfield
Aug 5, 1998·Biomaterials·M ZhangM Ferrari
Jul 9, 1999·Journal of Biomedical Materials Research·W B TsaiT A Horbett
Mar 27, 2001·Journal of Biomaterials Science. Polymer Edition·K ParkN L Eigler
Jan 27, 2004·Biomaterials·Hong ChenHeather Sheardown
May 13, 2005·Journal of Biomaterials Science. Polymer Edition·Hong ChenHeather Sheardown
Jun 28, 2005·Colloids and Surfaces. B, Biointerfaces·Anne Gry HemmersamFlemming Besenbacher
Sep 27, 2005·Biomaterials·Megan S LordBruce K Milthorpe
Nov 19, 2005·Expert Review of Medical Devices·Maria Cristina Tanzi
Oct 6, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Steven J GeelhoodMatthew J Quinn
Jul 5, 2007·Biomacromolecules·Dimitriya BozukovaChristine Jérôme
Aug 30, 2007·Biomacromolecules·Ranjini MurthyMelissa A Grunlan
Sep 28, 2007·The Lancet Infectious Diseases·Issam RaadDennis Maki
Dec 17, 2014·International Journal of Oral Science·Hong WuZhi-Jun Song
Feb 12, 2015·Journal of Medical Microbiology·Steven L PercivalGianfranco Donelli
Sep 5, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·M A RufinM A Grunlan
Sep 14, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Melissa L HawkinsMelissa A Grunlan

❮ Previous
Next ❯

Citations

Jul 31, 2019·Macromolecular Rapid Communications·Yajuan SuWei Huang
Nov 18, 2018·Soft Matter·Qingyi XieGuangzhao Zhang
Aug 20, 2020·Macromolecular Bioscience·Bryan Khai D NgoMelissa A Grunlan
Jun 8, 2019·Annual Review of Chemical and Biomolecular Engineering·Amanda K Leonardi, Christopher K Ober
Dec 4, 2020·Acta Biomaterialia·Manuel Quiñones-PérezMaribella Domenech
Feb 10, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria NowackaAnna Kowalewska
Jul 1, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Peng HuGuangzhao Zhang
Jul 13, 2021·Comprehensive Reviews in Food Science and Food Safety·Manon SagetMaude Jimenez
Feb 6, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Peng HuGuangzhao Zhang
Jan 19, 2021·ACS Biomaterials Science & Engineering·Bryan Khai D NgoMelissa A Grunlan

❮ Previous
Next ❯

Methods Mentioned

BETA
AFM
a
modified
ELISA
NMR
QCM-D
column chromatography
X-ray
immunosorbent assay
SMAs

Related Concepts

Related Feeds

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.