Anti-PRRSV effect and mechanism of sodium tanshinone IIA sulfonate in vitro

Journal of Asian Natural Products Research
Na SunHong-Quan Li

Abstract

This experiment was conducted to study the antiviral activities of sodium tanshinone IIA sulfonate (STS) against porcine reproductive and respiratory syndrome virus (PRRSV) and its mechanism. Anti-PRRSV activities of STS were observed on Marc-145 cells by using visualization of cytopathologic effect assay and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test, and its antiviral mechanism was determined by time-of-addition assay, adsorption inhibition assay, and virucidal assay. The results showed that STS could reduce the damage of PRRSV to Marc-145 cells, with the inhibition ratio exceeding to 100%, at the maximum non-cytotoxic concentration. The time-of-addition and virucidal assays indicated that the anti-PRRSV activities of STS could be due to inhibiting the virus replication or/and inactivating the virus directly. The inhibition of the virus attachment was not discovered in adsorption inhibition assay. The results proved that STS had strong anti-PRRSV activity and encouraged for further exploration of STS.

References

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Citations

Mar 5, 2016·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·D ChenY Chen
Oct 22, 2015·Journal of Asian Natural Products Research·Song-Lin ZhangJian-Feng Chen
Jun 13, 2014·Pharmaceutical Biology·Yaogui SunHongquan Li
Apr 23, 2013·International Journal of Biological Macromolecules·Jin-qiang ZhangHong-quan Li
Aug 28, 2020·Frontiers in Microbiology·God'spower Bello-OnaghiseYanhua Li
Sep 24, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhong-Yan ZhouJing-Yi Tang

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