Anti-Pseudomonas aeruginosa IgY antibodies promote bacterial opsonization and augment the phagocytic activity of polymorphonuclear neutrophils

Human Vaccines & Immunotherapeutics
K ThomsenN Høiby

Abstract

Moderation of polymorphonuclear neutrophils (PMNs) as part of a critical defense against invading pathogens may offer a promising therapeutic approach to supplement the antibiotic eradication of Pseudomonas aeruginosa infection in non-chronically infected cystic fibrosis (CF) patients. We have observed that egg yolk antibodies (IgY) harvested from White leghorn chickens that target P. aeruginosa opsonize the pathogen and enhance the PMN-mediated respiratory burst and subsequent bacterial killing in vitro. The effects on PMN phagocytic activity were observed in different Pseudomonas aeruginosa strains, including clinical isolates from non-chronically infected CF patients. Thus, oral prophylaxis with anti-Pseudomonas aeruginosa IgY may boost the innate immunity against Pseudomonas aeruginosa in the CF setting by facilitating a rapid and prompt bacterial clearance by PMNs.

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Citations

Jun 17, 2020·Experimental and Therapeutic Medicine·Carolina ConstantinDemetrios A Spandidos
Jun 23, 2020·Journal of Immunology Research·Fatemeh NorouziSeyed Latif Mousavi Gargari
Mar 12, 2021·Frontiers in Immunology·Claus MoserTim Tolker-Nielsen
Jun 29, 2021·Frontiers in Immunology·Lucia LeeDaria Mochly-Rosen

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Methods Mentioned

BETA
density gradient centrifugation
FACS

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GraphPad Prism
Zeiss Zen 2010
Excel

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