Anti-Quorum Sensing Activity of 12 Essential Oils on chromobacterium violaceum and Specific Action of cis-cis-p -Menthenolide from Corsican Mentha suaveolens ssp. Insularis

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Jean-Pierre PoliVannina Lorenzi

Abstract

Quorum sensing (QS) is a bacterial communication mechanism used to express various survival or virulence traits leading to enhanced resistance. Chromobacterium violaceum is a commonly used strain that highlights anti-QS action of bioactive substances. Here, we wanted to see if 12 selected essential oils (EO) could exert anti-QS activity. We measured the sublethal minimal QS inhibitory concentration (MQSIC) by assessing violacein production of C. violaceum along with bacterial growth. To confirm the QS disruption, we also proceed to surface bacterial observations using scanning electron microscopy (SEM). We showed that cis-cis-p-menthenolide extracted and isolated from a plant endemic to occidental Mediterranean Sea islands, Mentha suaveolens ssp. insularis, acts as an inhibitor of violacein production and biofilm formation. Measured MQSIC was much lower than the minimal inhibitory concentration (MIC): 0.10 mg·mL-1 vs. 3.00 mg·mL-1. Moreover, disturbance of QS-related traits was confirmed by the degradation of C. violaceum biofilm matrix. There is a clear structure⁻activity relationship between cis-cis-p-menthenolide and anti-QS activity. Indeed, its isomer molecule (mintlactone) exerts a poor anti-QS action. These results indic...Continue Reading

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Citations

Nov 14, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ramaiana Soares MeloVictor Alves Carneiro
Dec 1, 2020·Critical Reviews in Food Science and Nutrition·Chiara RossiAntonello Paparella
Dec 15, 2020·The Plant Pathology Journal·Adamu AbdullahiMohd Razi Ismail
Dec 18, 2020·Comprehensive Reviews in Food Science and Food Safety·Dan ZhangHarold Corke

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scanning electron microscopy
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scanning electron micrographies

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