Anti-RANKL therapy for bone tumours: Basic, pre-clinical and clinical evidences

Journal of Bone Oncology
Dominique Heymann

Abstract

Bone remodelling is related to coordinated phases of bone resorption and bone apposition allowing the maintenance of bone integrity, the phosphocalcic homoeostasis all along the life and consequently the bone adaptation to mechanical constraints or/and to endocrine fluctuations. Unfortunately, bone is a frequent site of tumour development originated from bone cell lineages (primary bone tumours: bone sarcomas) or from nonosseous origins (bone metastases: carcinomas). These tumour cells disrupt the balance between osteoblast and osteoclast activities resulting in a disturbed bone remodelling weakening the bone tissue, in a strongly altered bone microenvironment and consequently facilitating the tumour growth. At the early stage of tumour development, osteoclast differentiation and recruitment of mature osteoclasts are strongly activated resulting in a strong bone matrix degradation and release of numerous growth factors initially stored into this organic/calcified matrix. In turn these soluble factors stimulate the proliferation of tumour cells and exacerbate their migration and their ability to initiate metastases. Because Receptor Activator of NFκB Ligand (RANKL) is absolutely required for in vivo osteoclastogenesis, its role ...Continue Reading

Citations

Mar 13, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Irene QuattriniMaria Serena Benassi
Dec 10, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Riadh BadraouiTarek Rebai
Jan 7, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Stéphane TéletchéaDominique Heymann
Apr 9, 2016·International Journal of Molecular Sciences·Atik Badshah ShaikhGe Zhang
Jan 11, 2016·The FEBS Journal·Eva González-Suárez, Adrián Sanz-Moreno
Nov 13, 2013·Cancers·Kosei AndoDominique Heymann
Mar 1, 2013·Balsaeng'gwa saengsig·Yoon-Young Sung, Chul-Sang Lee
Jul 29, 2018·Proteomics. Clinical Applications·Amalia ContiLaura Pazzaglia
Mar 31, 2021·Clinical and Translational Medicine·Young Jong KoWonbong Lim
Jul 3, 2021·International Journal of Molecular Sciences·Kirstine Sandal NørregaardKent Søe
Oct 23, 2021·British Journal of Pharmacology·Zunaira ShoaibJoseph M K Irudayaraj

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Methods Mentioned

BETA
antisense oligodeoxyribonucleotide

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