Anti-RANKL treatment improves screw fixation in cancellous bone in rats

Injury
Magnus BernhardssonPer Aspenberg

Abstract

Bisphosphonates improve implant fixation in randomised clinical trials of knee prostheses, hip prostheses and dental implants. However, a limited amount of bone resorption is required for bisphosphonates to exert an effect. Anti-RANKL treatment does not have this limitation, and we therefore tested whether if they might be more effective for improvement of implant fixation. This is of interest, as anti-RANKL treatment with denosumab is now in common clinical use. Male SD rats received a stain-less steel screw in the right proximal tibia and a drill hole in the left (n = 42). They were randomised to subcutaneous injections of either alendronate (20 μg/kg/day), alendronate (200 μg/kg/day), osteoprotegerin with an Fc tag (OPG-Fc; 8 mg/kg, twice weekly), or saline control. After 4 weeks, the fixation of the steel screw was measured by pull-out test. The tibia with the drill hole was evaluated with μCT. OPG-Fc increased the pull-out force compared to saline controls by 153% (p < 0.001). There was no significant difference between OPG-Fc and the alendronate groups. OPG-Fc increased the bone density (BV/TV) in the previous drill hole compared to controls 7-fold (p < 0.001). This increase was higher than with any alendronate dose (p < ...Continue Reading

References

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Citations

Jan 28, 2017·Acta Orthopaedica·Love TättingPer Aspenberg
Dec 30, 2016·Drug Metabolism Reviews·Dragos ApostuSimion Bran
Mar 14, 2017·Acta Orthopaedica·Håkan LedinPer Aspenberg
May 28, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Olof SandbergPer Aspenberg
May 23, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Lucian B SolomonGerald J Atkins
Jan 24, 2019·Current Osteoporosis Reports·Cheng Cheng, Dolores Shoback
Oct 14, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Joseph H ChoiMathias P G Bostrom
Mar 28, 2021·Journal of Orthopaedic Surgery and Research·Soji TaniKatsunori Inagaki
Nov 13, 2020·Acta Biomaterialia·Mohammed MahriFaleh Tamimi

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