Anti-receptor antibody-induced suppression of murine H-Y-specific delayed-type hypersensitivity responses

European Journal of Immunology
M E SundayM E Dorf

Abstract

A putative anti-H-Y receptor antiserum (ARA) was raised in C57BL/6 male mice against splenic T lymphocytes from syngeneic females immunized against H-Y antigen. When this antiserum is given i.v. to C57BL/6 females it prevents the expression of H-Y-specific delayed-type hypersensitivity (DTH). The suppressive activity in ARA was selectively retained on rabbit anti-mouse immunoglobulin columns, and could be absorbed by H-Y-immune spleen cells from C57BL/6 female mice. The abrogation of H-Y DTH reactivity was at least in part due to the generation of suppressor T cells which are generated by ARA in naive female mice. ARA-generated suppressor cells specifically inhibit the induction phase of DTH responses to the H-Y antigen, having no effect on (4-hydroxy-3-nitrophenyl)acetyl (NP)-specific cutaneous sensitivity responses or on DTH responses to minor histocompatibility antigens. Furthermore, there is a requirement for Igh gene homology between the strain producing the ARA and the strain in which the DTH response is induced. Thus, C57BL/6 ARA given to A.BY (H-2b, Igh-1e) or to B.C-8 (H-2b, Igh-1a) mice was unable to suppress homologous H-Y DTH responses in these strains. However, C57BL/6 ARA induced suppressor cells in B.C-8 mice whi...Continue Reading

References

Jan 1, 1976·Scandinavian Journal of Immunology·C A JanewayH Binz
Jan 1, 1977·Immunological Reviews·H RamseierJ Lindenmann
Jan 1, 1977·Contemporary Topics in Immunobiology·H Binz, H Wigzell
Jan 1, 1981·Scandinavian Journal of Immunology·B Benacerraf, R N Germain

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Citations

Aug 1, 1982·The Journal of Experimental Medicine·M MinamiM E Dorf
May 1, 1983·The Journal of Experimental Medicine·M MinamiM E Dorf
Jan 1, 1982·Annals of the New York Academy of Sciences·H Binz Wigzell

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