Anti-resorptive effect of pamidronate on extraction socket wall in dogs

Clinical Oral Implants Research
Jae-Kook ChaUi-Won Jung

Abstract

The aim of this experimental in vivo investigation was to assess the anti-resorptive effect of low concentration pamidronate on the buccal plate in fresh extraction sockets. The distal roots of the third premolars were extracted bilaterally in six dogs. A collagen matrix loaded with either pamidronate (test group) or saline (control group) was positioned on the outer surface of buccal bone immediately after tooth extraction and subsequently covered with a coronally advanced flap. Histological and histomorphometric outcomes were evaluated 12 weeks later. The mean vertical distance between the buccal and lingual bone crest differed significantly between the test and control groups (0.52 ± 0.43 and 2.21 ± 1.15 mm, respectively; p = .037). The width of the buccal bone 1 mm below the crest was significantly wider in the test group than the control group (4.68 ± 0.68 vs. 3.44 ± 0.60 mm, p < .001). Local application of pamidronate onto a collagen matrix may reduce the dimensional changes of the buccal bone plate both vertically and horizontally.

References

Mar 1, 1972·Journal of Periodontology·D L WoodL D Rosenfeld
Mar 7, 2002·Breast Cancer Research : BCR·Herbert Fleisch
Feb 21, 2003·Journal of Periodontology·Avinoam YaffeItzhak Binderman
Aug 4, 2004·International Journal of Oral and Maxillofacial Surgery·H Altundal, O Güvener
Feb 5, 2005·Journal of Clinical Periodontology·Mauricio G Araújo, Jan Lindhe
Feb 20, 2007·Journal of Periodontal Research·B HoushmandB Eslami
Jul 28, 2007·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Suthasiny SrisubutSuwimol Taweechaisupapong
Nov 6, 2008·Clinical Oral Implants Research·Stefan FicklMarkus B Huerzeler
Jan 2, 2009·The New England Journal of Medicine·Robert S WeinsteinStavros C Manolagas
Nov 26, 2010·Clinical Oral Implants Research·J M A G Ten HeggelerG A Van der Weijden
Jan 11, 2012·Clinical Oral Implants Research·Fabio VignolettiMariano Sanz
Sep 14, 2012·Clinical Oral Implants Research·Ji-Youn HongChong-Kwan Kim
Mar 29, 2013·Journal of Clinical Periodontology·Nicola DiscepoliMariano Sanz
Jul 23, 2013·The International Journal of Oral & Maxillofacial Implants·Jian LiaoXing Liang
Jul 22, 2014·Clinical Oral Implants Research·Nicola DiscepoliMariano Sanz

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Citations

Oct 27, 2018·Evidence-based Dentistry·Aya K Khamis, Sherif Elsharkawy
Sep 19, 2020·Scientific Reports·Jeong Hyun HaSukwha Kim
May 24, 2020·International Journal of Molecular Sciences·Frederic KauffmannRico Rutkowski

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