PMID: 9440142Jan 1, 1997Paper

Anti-Ro (SSA) antibodies in rheumatoid arthritis patients with gold-induced side effects

Rheumatology International
M TishlerM Yaron

Abstract

The purpose of our study was to investigate the significance of the presence of anti-Ro antibodies found by us in an earlier study of rheumatoid arthritis (RA) patients with gold-induced side effects. Sera of 29 anti-Ro (SSA) positive RA patients who had gold-induced side effects were studied. All sera were examined by Western blot using recombinant antigens, encoding the Ro 60 kD and the La proteins. HLA typing was done in all patients. Thirteen patients reacted only with the Ro 52 kD antigen and all had severe skin eruptions caused by gold therapy. Another ten patients who reacted only with the Ro 60 kD antigen had other side effects to gold (six had proteinuria and four leucopenia). Six patients who reacted to all three antigens (Ro 52 kD, Ro 60 kD and La) had secondary Sjögren's syndrome. No significant statistical differences were noted in the incidence of HLA-DR3 between the subgroups of patients. Our data indicated that antibodies to the Ro 52 kD antigen are associated with skin eruptions in RA patients treated with gold.

Citations

Jan 10, 2008·Clinical Rheumatology·Emilce SchneebergerJosé Maldonado Cocco
Sep 30, 1999·Environmental Health Perspectives·P E Bigazzi
Feb 7, 2020·Rheumatology·Florian Kollert, Benjamin A Fisher
Jun 30, 1998·Scandinavian Journal of Rheumatology·M TishlerM Yaron

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.