Anti-ro52 antibodies and interstitial lung disease in connective tissue diseases excluding scleroderma.

ISRN Rheumatology
João Pedro FerreiraCarlos Vasconcelos

Abstract

Introduction. The presence of anti-Ro52 antibodies has been reported in a wide variety of autoimmune diseases, particularly in myositis, scleroderma, and autoimmune liver diseases. Clinical significance of anti-Ro52 antibodies remains controversial, and studies are lacking for clarifying the association of anti-Ro52 with interstitial lung disease (ILD) in connective tissue diseases (CTD). Objectives. To determine if anti-Ro52 antibodies are associated with ILD in CTD other than scleroderma. Methods. Single-center, retrospective study based on immunoblotting panel analysis and patients clinical records. Results. In our connective tissue disease cohort, 162 patients had immunoblotting panels with anti-Ro52 reactivity analysis, 41 (25,3%) had inclusion criteria. Among the 41 selected sera, 85.4% (n = 35) had anti-Ro52 reactivity. The prevalence of ILD in the positive anti-Ro52 antibodies was 71.4% (n = 25), and 16.7% (n = 1) in the negative anti-Ro52 group (P = 0.018). Overall sensitivity (96.2%), specificity (83.3%), positive (71.4%) and negative (83.3%) predictive values of anti-Ro52 antibodies to determine ILD in CTD is detailed in this study. Conclusion. Ro52 autoantibodies are associated with ILD in CTD excluding scleroderma....Continue Reading

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Citations

Jul 17, 2016·Best Practice & Research. Clinical Rheumatology·Joanna TieuVidya Limaye
Nov 1, 2016·Current Rheumatology Reports·Lindsay B KelmensonKevin D Deane
Mar 16, 2018·Clinical and Molecular Allergy : CMA·Boaz PaltererPaola Parronchi
Sep 9, 2019·BMJ Case Reports·Uthara MathewAnimesh Ray
Jun 7, 2019·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Elopy Sibanda, Nancy Makaza
Aug 31, 2019·Case Reports in Rheumatology·D A Vargas-GutiérrezS Velázquez de la Paz
Jan 28, 2020·Current Treatment Options in Rheumatology·Courtney ShappleyLesley Ann Saketkoo
Nov 20, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Hung-Ling HuangYuan-Ting Sun
Jan 3, 2021·The American Journal of the Medical Sciences·Woon H ChongScott Beegle

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Methods Mentioned

BETA
bronchoalveolar lavage

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EUROLINE
SPSS
Excel

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