PMID: 9166002Apr 1, 1997Paper

Anti-Ro/SS-A and anti-La/SS-B antibodies associated with cardiac involvement in childhood systemic lupus erythematosus

Annals of the Rheumatic Diseases
A C OshiroA Gedalia

Abstract

To determine the frequency and type of cardiac manifestations in children with systemic lupus erythematosus (SLE) and investigate whether cardiac involvement of SLE in children was associated with any autoantibody pattern. Retrospective analysis of the medical records of all children with SLE (31 patients) seen between January 1984 and January 1994 by the paediatric rheumatology service at Children's Hospital in New Orleans. All patients satisfied the American College of Rheumatology criteria for the diagnosis of SLE. Paediatric SLE patients with cardiac manifestations based on echocardiogram were identified. Autoantibody tests at diagnosis were identified retrospectively by chart review, and the correlation between autoantibodies and cardiac involvement was analysed using the two tailed Fisher's exact test. Thirteen (42%) of 31 SLE patients had cardiac manifestations of SLE. Seven (22%) had pericarditis without myocarditis, five (16%) had pericarditis and myocarditis, and one (3%) had myocarditis without pericarditis. Two patients (6%) with pericarditis had cardiac tamponade. Cardiac manifestations of SLE usually occurred at the time of diagnosis or within six months. Anti-Ro/SS-A antibodies were present in serum samples of ni...Continue Reading

Citations

Dec 8, 2009·Pediatric Cardiology·Cory StinglBryce A Binstadt
Jul 27, 2000·Journal of Clinical Pathology·W Egner
Nov 26, 2008·Clinical Rheumatology·Márcio Veronesi FukudaSamuel Katsuyuki Shinjo
Mar 24, 2010·Pediatric Clinics of North America·Francesca MilanettiRichard K Burt
Mar 25, 2015·Pediatric Rheumatology Online Journal·Satish S Maharaj, Simone M Chang
Nov 24, 1999·International Journal of Dermatology·E García-GonzálezJ Granados
Nov 7, 2019·Pediatric Rheumatology Online Journal·D O'LearyO G Killeen
Jul 25, 2021·International Journal of Molecular Sciences·James Greenan-BarrettCoziana Ciurtin

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