Anti-SARS-CoV-2 neutralizing monoclonal antibodies: clinical pipeline.

MAbs
Marco TuccoriDaniele Focosi

Abstract

Monoclonal antibody (mAb) therapy has been previously exploited for viral infections, such as respiratory syncytial virus pneumonia and Ebolavirus disease. In the ongoing COVID-19 pandemic, early signals of efficacy from convalescent plasma therapy have encouraged research and development of anti-SARS-CoV-2 mAbs. While many candidates are in preclinical development, we focus here on anti-SARS-CoV-2 neutralizing mAbs (or mAb cocktails) that represent the late-stage clinical pipeline, i.e., those currently in Phase 2 or Phase 3 clinical trials. We describe the structure, mechanism of action, and ongoing trials for VIR-7831, LY-CoV555, LY-CoV016, BGB-DXP593, REGN-COV2, and CT-P59. We speculate also on the next generation of these mAbs.

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Citations

Feb 9, 2021·Journal of Ovarian Research·Antonio MacciòClelia Madeddu
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Methods Mentioned

BETA
single-cell sequencing
phage display

Clinical Trials Mentioned

NCT04425629
NCT04426695
NCT04452318
NCT04381936
NCT04411628
NCT04427501
NCT04497987
NCT04501978
NCT04518410
NCT04545060

Software Mentioned

Celltrion
BeiGene
Google Scholar

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